| Effects of endothelin on microcirculation of the pancreas. | |
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MedLine Citation:
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PMID: 1640812 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Endothelin, a newly described endothelial-derived peptide, has potent vasoconstrictive properties and has been speculated to play a physiological role in the regulation of blood flow in some organs. The present study was designed to evaluate the effects of endothelin-1, endothelin-2 and endothelin-3 on the pancreatic microcirculation. Pancreatic tissue blood flow was measured by a laser Doppler flow meter in anesthetized dogs and endothelin-1, endothelin-2 or endothelin-3 was injected intravenously in graduated doses. Endothelins induced dose-dependent decreases in pancreatic tissue blood flow. Endothelin-1, endothelin-2 and endothelin-3 at a dose of 100 pmol/kg reduced pancreatic blood flow by 45.4%, 19.6% and 51.9%, respectively, whereas systemic arterial blood pressure was not significantly affected. When endothelin-3 was administered at a dose of 1000 pmol/kg, pancreatic blood flow was decreased by 73.5% with a concomitant increase of systemic arterial blood pressure by 17.6%. Endothelins potently decreased pancreatic tissue blood flow, suggesting a possible role of these agents in regulating the pancreatic microcirculation. |
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Authors:
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K Takaori; K Inoue; M Kogire; S Higashide; T Tun; T Aung; R Doi; N Fujii; T Tobe |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Life sciences Volume: 51 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1992 |
Date Detail:
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Created Date: 1992-09-01 Completed Date: 1992-09-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 615-22 Citation Subset: IM |
Affiliation:
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First Department of Surgery, Faculty of Medicine, Kyoto University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Blood Pressure / physiology Dogs Endothelins / physiology* Female Injections, Intravenous Male Microcirculation / physiology Pancreas / blood supply* Regional Blood Flow / physiology |
| Chemical | |
Reg. No./Substance:
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0/Endothelins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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