| Effects of endothelin-1 on the rat testicular vasculature. | |
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MedLine Citation:
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PMID: 8889698 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Endothelin-1 (ET-1), a well-known vasoconstrictor substance, is present in the testis but its functional role is unknown. The present study was undertaken to elucidate whether ET-1 may influence testicular blood flow. ET-1 (0.1, 1, 10, 100 ng), an ETA antagonist (BQ123; 0.01, 1, 100 micrograms), or saline were administered by intratesticular injections (0.1 ml) in adult rats. The effect on testicular blood flow was monitored using a laser Doppler flowmeter. The localization of immunoreactive ET-1 (irET-1) was studied by immunohistochemistry and the testicular irET-1 concentration was measured in normal and human chorionic gonadotrophin (hCG)-treated rats using a radioimmunoassay. ET-1 injection, in a dose-related way acutely decreased testicular blood flow and this effect was blocked by an ETA antagonist. The antagonist itself did not, however, influence testicular blood flow. Accumulation of polymorphonuclear leukocytes was observed in testicular venules 2 hours after ET-1 injection. Immunoreactive ET-1 was observed in Leydig, Sertoli, and endothelial cells. The testicular irET-1 content was increased 2-fold by hCG stimulation but local injection of the ET-1 antagonist did not influence testicular blood flow in hCG-treated rats. The present study suggests that ET-1 could be a hormonally regulated and locally produced modulator of testicular blood flow and microcirculation. |
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Authors:
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O Collin; J E Damber; A Bergh |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of andrology Volume: 17 ISSN: 0196-3635 ISO Abbreviation: J. Androl. Publication Date: 1996 Jul-Aug |
Date Detail:
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Created Date: 1996-12-26 Completed Date: 1996-12-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8106453 Medline TA: J Androl Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 360-6 Citation Subset: IM |
Affiliation:
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Department of Anatomy, Umeå University, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Endothelin-1 / pharmacology* Immunohistochemistry Leukocyte Count Male Neutrophils / cytology Radioimmunoassay Rats Rats, Sprague-Dawley Regional Blood Flow / drug effects Testis / blood supply* Veins / cytology |
| Chemical | |
Reg. No./Substance:
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0/Endothelin-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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