| Effects of endothelin-1 on isolated uterine horns in estrogen-primed and pregnant mice. | |
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MedLine Citation:
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PMID: 8010105 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mouse uterine horns from 4 states (estrogen-primed and early-, mid-, and late-pregnancy) were used to study the effect of endothelin-1 (ET) vs carboprost (Car) and oxytocin (Oxy). In K(+)-Krebs (KCl 40 mmol.L-1) solution, ET (1-300 nmol.L-1), Car (0.002-20 mumol.L-1), and Oxy (0.6-60 nmol.L-1) evoked concentration-dependent increases in tension of the uterine horns from 4 different states. Emax for ET were 1.12 +/- 0.26, 1.27 +/- 0.18, and 1.49 +/- 0.13 g in early-, mid-, and late-pregnancies, respectively. Emax for Car in mid- was twice that in late-pregnancy, whereas Emax for Oxy in late- was thrice that in mid-pregnancy. EC50 for ET were 9.6, 5.8, and 6.3 nmol.L-1 in early-, mid-, and late-pregnancies, respectively, and were only 2% to 7% of that for Car and 3-15 times of that for Oxy in various gravid stages. The results suggest that the contractile activity of pregnant mouse uterus to ET is more potent than that of Car while slightly weaker than that of Oxy. |
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Authors:
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Q Y Gong; L A Chen; J Z Li; W H Xu; Z C Yang |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Zhongguo yao li xue bao = Acta pharmacologica Sinica Volume: 15 ISSN: 0253-9756 ISO Abbreviation: Zhongguo Yao Li Xue Bao Publication Date: 1994 Mar |
Date Detail:
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Created Date: 1994-07-19 Completed Date: 1994-07-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8100330 Medline TA: Zhongguo Yao Li Xue Bao Country: CHINA |
Other Details:
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Languages: eng Pagination: 129-32 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, School of Basic Medical Sciences, Shanghai Medical University, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carboprost / pharmacology Dose-Response Relationship, Drug Endothelins / pharmacology* Female Mice Oxytocin / pharmacology Pregnancy Pregnancy, Animal / physiology* Uterine Contraction / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Endothelins; 35700-23-3/Carboprost; 50-56-6/Oxytocin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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