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Effects of endothelin-1 chronic stimulation on electrical restitution, beat-to-beat variability of repolarization and ventricular arrhythmogenesis.
MedLine Citation:
PMID:  24084217     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Chronically elevated levels of endothelin-1 (ET-1) have been detected in several cardiovascular diseases. In this study, we investigated the chronic effects of ET-1 on the electrophysiological characteristics expected to influence the genesis and maintenance of ventricular arrhythmia (VA). Rabbits were randomized to ET-1 (ET-1 group) or 0.9% saline (control group) for 2 weeks. The S1-S2 protocol and S1-S1 dynamic pacing were performed to assess the action potential duration restitution (APDR) and to induce APD alternans or VA in four sites of Langendorff-perfused rabbit hearts. The beat-to-beat variability of repolarization (BVR) was quantified as short-term variability (STV) and long-time variability (LTV). Compared with the control group, chronic ET-1 administration significantly prolonged QT intervals, APD90 and ERP, steepened the maximum slopes (Smax) of the APDR curve, decreased the ERP/APD90 ratio and increased the spatial dispersions of APD90, ERP and Smax (P <0.05 for all). Moreover, chronic ET-1 administration markedly increased the STV and LTV (P <0.01 for all). APD alternans occurred in both groups, but the threshold of APD alternans was decreased at all sites in the ET-1 group (P <0.01 for all). We also observed that chronic ET-1 stimulation significantly increased the incidence and duration of the VA episodes. These results suggest that chronic stimulation with ET-1 facilitated VA by steepening the APDR curve and increasing the spatial dispersion of APDR and BVR.
Authors:
Tao Liu; Mu Qin; Shaobo Shi; Zhen Chen; Teng Wang; Congxin Huang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-9-30
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  -     ISSN:  1533-4023     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-10-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
aDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China bCardiovascular Research Institute, Wuhan University, Wuhan 430060, China cThe first clinical medical college of three gorges university, Yichang443000, China dDepartment of Emergency, Central Hospital of Wuhan, Wuhan 430014, China.
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