Document Detail


Effects of endocrine disruptors on prosobranch snails (Mollusca: Gastropoda) in the laboratory. Part II: Triphenyltin as a xeno-androgen.
MedLine Citation:
PMID:  11214444     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In laboratory experiments the effects of suspected endocrine disrupting chemicals on freshwater and marine prosobranch species were analysed. In this second of three publications the responses of the freshwater ramshorn snail Marisa cornuarietis and of two marine prosobranchs (the dogwhelk Nucella lapillus and the netted whelk Hinia reticulata) to the xeno-androgenic model compound triphenyltin (TPT) are presented. Marisa and Nucella were exposed via water (nominal concentrations 5-500 ng TPT-Sn/L) and Hinia via sediments (nominal concentrations 50-500 micrograms TPT-Sn/kg dry wt.) for up to 4 months. Female ramshorn snails but not the two marine species developed imposex in a time and concentration dependent manner (EC10 4 months: 12.3 ng TPT-Sn/L) with a comparable intensity as described for tributyltin. TPT reduced furthermore the fecundity of Marisa at lower concentrations (EC10 4 months: 5.59 ng TPT-Sn/L) with a complete inhibition of spawning at nominal concentrations > or = 250 ng TPT-Sn/L (mean measured +/- SD: > or = 163 +/- 97.0 ng TPT-Sn/L). The extension of the pallial sex organs (penis with accessory structures and prostate gland) of male ramshorn snails and dogwhelks were reduced by up to 25% compared to the control but not in netted whelks. Histopathological analyses for M. cornuarietis and H. reticulata provide evidence for a marked impairment of spermatogenesis (both species) and oogenesis (only netted whelks). The test compound induced a highly significant and concentration independent increase in the incidence of hyperplasia on gills, osphradia and other organs in the mantle cavity of N. lapillus indicating a carcinogenic potential of TPT. The results show that prosobranchs are sensitive to endocrine disruption at environmentally relevant concentrations of TPT. Also, M. cornuarietis is a promising candidate for a future organismic invertebrate system to identify endocrine-mimetic test compounds.
Authors:
U Schulte-Oehlmann; M Tillmann; B Markert; J Oehlmann; B Watermann; S Scherf
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Ecotoxicology (London, England)     Volume:  9     ISSN:  0963-9292     ISO Abbreviation:  Ecotoxicology     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2001-02-14     Completed Date:  2001-04-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9885956     Medline TA:  Ecotoxicology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  399-412     Citation Subset:  IM    
Affiliation:
Internationales Hochschulinstitut Zittau, Lehrstuhl Umweltverfahrenstechnik, Fachgruppe Human- und Okotoxikologie, Markt 23, D-02763 Zittau, Germany. oehlmann@ihi-zittau.de
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MeSH Terms
Descriptor/Qualifier:
Androgens / pharmacology*
Animals
Female
Fresh Water
Male
Organotin Compounds / pharmacology*
Pesticides / pharmacology*
Seawater
Snails / drug effects*
Water Pollutants, Chemical / pharmacology*
Chemical
Reg. No./Substance:
0/Androgens; 0/Organotin Compounds; 0/Pesticides; 0/Water Pollutants, Chemical; 892-20-6/triphenyltin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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