Document Detail

Effects of endocrine disruptors on developmental and reproductive functions.
MedLine Citation:
PMID:  15777200     Owner:  NLM     Status:  MEDLINE    
Endocrine disruptors (EDs) are exogenous environmental molecules that may affect the synthesis, secretion, transport, metabolism, binding, action, and catabolism of natural hormones in the body. EDs may thus interact with the endocrine system of animals and humans and can exert this effect even when present in minute amounts. EDs have adverse impacts on a number of developmental functions in wildlife and humans. Critical periods of urogenital tract and nervous system development in-utero and during early post-natal life are especially sensitive to hormonal disruption. Furthermore a wide range of hormone-dependent organs (pituitary gland, hypothalamus, reproductive tract) are targets of EDs disrupting effects in adult subjects, possibly resulting in cell transformation and cancer. At present about 60 chemicals have been identified and characterized as EDs and belong to three main groups: (a) synthetic compounds utilized in industry, agriculture and consumer products; (b) synthetic molecules used as pharmaceutical drugs and (c) natural chemicals found in human and animal food (phytoestrogens). In the present review we will give special attention to the family of Polychlorinated biphenyls (also indicated as PCBs) because of their persistence in the environment, ability to concentrate up the food chain, continued detection in environmental matrices, and ability to be stored in the adipose tissue of animals as well as humans. The detrimental effects of these compounds, and of EDs more in general, on health and reproduction will be discussed, presenting experimental data aimed at understanding the molecular mechanisms involved in their action.
Tiziana A L Brevini; Simona Bertola Zanetto; Fabiana Cillo
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current drug targets. Immune, endocrine and metabolic disorders     Volume:  5     ISSN:  1568-0088     ISO Abbreviation:  Curr. Drug Targets Immune Endocr. Metabol. Disord.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-03-21     Completed Date:  2005-04-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101121150     Medline TA:  Curr Drug Targets Immune Endocr Metabol Disord     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1-10     Citation Subset:  IM    
Department of Anatomy of Domestic Animals, School of Veterinary Medicine, University of Milano, Italy.
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MeSH Terms
Endocrine System / drug effects*,  metabolism,  physiology*
Environmental Exposure / adverse effects*
Hormone Antagonists / chemistry,  metabolism*,  toxicity*
Reproduction / drug effects*,  physiology*
Reg. No./Substance:
0/Hormone Antagonists

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