Document Detail

Effects of enalapril in cats with pressure overload-induced left ventricular hypertrophy.
MedLine Citation:
PMID:  16934512     Owner:  NLM     Status:  MEDLINE    
In order to evaluate the effect of enalapril on haemodynamics and renal function in a pressure overload model, we prepared eight feline models of left ventricular hypertrophy (LVH) by banding of the aortic arch. The LVH cats were assigned to the placebo group or the enalapril group (0.5 mg/kg, PO, sid) 3 months following surgery, and each received its respective drug for 4 weeks. Each week, blood pressure, angiotensin converting enzyme (ACE) activity in blood, and creatinine clearance were measured, and complete blood count (CBC), biochemical examination of the blood, echocardiography, and chest radiography were carried out. The interventricular septum thickness (IVSd, IVSs), fractional shortening (FS), and ejection fraction (EF) increased significantly in the LVH cats following surgery (P<0.05). There was no significant difference between the placebo group and the enalapril group with respect to general physical parameters, CBC, biochemical parameters and renal function. In the enalapril group, systolic arterial pressure, mean arterial pressure, and ACE activity in blood decreased significantly following administration (P<0.05). In addition, the left ventricular free wall thickness in diastole and IVSd decreased significantly following administration (P<0.05). These results suggest that, in a pressure overload model, enalapril (0.5 mg/kg, sid) inhibits cardiac hypertrophy, reduces blood pressure, and does not adversely affect renal function.
Yumi Ishikawa; Masami Uechi; Yasutomo Hori; Takashi Ebisawa; Shigeki Yamano; Youko Enomoto; Jun Ugai
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-08-23
Journal Detail:
Title:  Journal of feline medicine and surgery     Volume:  9     ISSN:  1098-612X     ISO Abbreviation:  J. Feline Med. Surg.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-02     Completed Date:  2007-04-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100897329     Medline TA:  J Feline Med Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  29-35     Citation Subset:  IM    
Veterinary Teaching Hospital, Kitasato University, 23-35-1 Higashi, Towada, Aomori 034-8628, Japan.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / administration & dosage*
Blood Pressure / drug effects
Cat Diseases / drug therapy*,  surgery*
Enalapril / administration & dosage*
Hypertrophy, Left Ventricular / drug therapy,  surgery,  veterinary*
Models, Animal
Ventricular Function, Left / drug effects
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 75847-73-3/Enalapril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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