Document Detail

Effects of enalapril on the exercise capacity and neurohumoral factors during exercise in patients with chronic heart failure.
MedLine Citation:
PMID:  8960618     Owner:  NLM     Status:  MEDLINE    
The effects of enalapril on exercise capacity and neurohumoral factors during exercise were evaluated in 10 patients with heart failure. Echocardiograms and exercise testing with expired gas analysis were performed before and after enalapril. Blood samples were obtained before and after exercise. Both ejection fraction and percent fractional shortening increased with enalapril (p < 0.05). The anaerobic threshold and peak VO2 did not change with enalapril. Epinephrine and norepinephrine levels at peak exercise decreased with enalapril (p < 0.1). Plasma renin both at rest and at peak exercise increased with enalapril (p < 0.1). Angiotensin II was lower after enalapril both at rest and at peak exercise (p < 0.1 and p < 0.05, respectively). Aldosterone was lower after enalapril both at rest and at peak exercise (p < 0.05). Atrial natriuretic peptide (ANP) was lower after enalapril both at rest and at peak exercise. There was no significant correlations between peak VO2 and changes in neurohumoral factors before and after enalapril during exercise. In conclusion, neurohumoral changes with enalapril occurred during exercise even if exercise capacity did not improve. Moreover, the improvement of cardiac function at rest and neurohumoral factors with enalapril did not lead to a change of exercise capacity.
K Ogino; M Kato; N Noguchi; H Kitamura; S Osaki; H Omodani; T Matsumoto; T Kinugawa; H Miyakoda; H Kotake; H Mashiba
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiology     Volume:  88     ISSN:  0008-6312     ISO Abbreviation:  Cardiology     Publication Date:    1997 Jan-Feb
Date Detail:
Created Date:  1997-03-10     Completed Date:  1997-03-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  6-13     Citation Subset:  IM    
First Department of Internal Medicine, Tottori University School of Medicine, Yonago, Japan.
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MeSH Terms
Aged, 80 and over
Anaerobic Threshold / drug effects
Angiotensin-Converting Enzyme Inhibitors / administration & dosage*
Blood Gas Analysis
Chronic Disease
Dose-Response Relationship, Drug
Enalapril / administration & dosage*
Exercise / physiology*
Exercise Tolerance / drug effects*
Heart Failure / blood,  diagnosis,  drug therapy,  physiopathology*
Middle Aged
Neurotransmitter Agents / blood
Radiography, Thoracic
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Neurotransmitter Agents; 75847-73-3/Enalapril

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