Document Detail


Effects of enalapril and Dup753 on renin synthesis in mice with one hydronephrotic kidney.
MedLine Citation:
PMID:  8039266     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Renin synthesis and secretion were investigated in mice with one hydronephrotic kidney. 2. Enalapril and Dup753 stimulated renin synthesis to a similar extent in the hydronephrotic and normal kidney. 3. Hydronephrosis did not prevent an increase in renin mRNA caused by enalapril and Dup753. 4. The results therefore indicate that the macula densa does not appear to be crucial for renin synthesis in the kidney under the inhibition of angiotensin II. 5. Thus angiotensin II plays an important role controlling renin gene expression in both the normal and hydronephrotic kidneys.
Authors:
Y Zhang; T Morgan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  21     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-08-22     Completed Date:  1994-08-22     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  133-5     Citation Subset:  IM    
Affiliation:
Department of Physiology, University of Melbourne, Parkville, Victoria, Australia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antihypertensive Agents / pharmacology*
Biphenyl Compounds / pharmacology*
Enalapril / pharmacology*
Hydronephrosis / metabolism*
Imidazoles / pharmacology*
Kidney / drug effects,  metabolism*
Kidney Tubules, Distal / drug effects,  metabolism
Losartan
Male
Mice
Mice, Inbred BALB C
RNA, Messenger / biosynthesis
Renin / biosynthesis*,  blood
Tetrazoles / pharmacology*
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Biphenyl Compounds; 0/Imidazoles; 0/RNA, Messenger; 0/Tetrazoles; 114798-26-4/Losartan; 75847-73-3/Enalapril; EC 3.4.23.15/Renin

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