| Effects of enadoline on the development of pentylenetetrazol kindling, learning performance, and hippocampal morphology. | |
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MedLine Citation:
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PMID: 10095026 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Opioids are involved in the development of epileptic seizures. Recently, interest has been focused on the role of the kappa-opioid receptor agonists as novel approaches to the treatment of epilepsy. In the present study we investigated the effects of the kappa-opioid receptor agonist enadoline (Ena) on pentylenetetrazol (PTZ) induced seizures, PTZ kindling, shuttle-box performance and hippocampal neuromorphology. Ena injected i.c.v. in doses of 1 and 10 nmol did not affect acute PTZ seizures. In the course of PTZ kindling development, co-treatment (1 nmol) with the kappa-opioid receptor agonist suppressed seizure strength. Eight days after kindling completion the animals received a challenge dose of PTZ. In reaction to challenge, kindled animals which were pretreated with Ena reached significantly lower seizure scores. Kindling resulted in diminished shuttle-box performance. Learning performance in kindled animals pretreated with Ena was not normalised. Kindling resulted in increased glutamate binding. Interestingly, in comparison with the saline/saline group, neither in the Ena/saline nor in the Ena/PTZ treated groups changes in glutamate binding were found. That means that Ena prevented the increase in glutamate binding in the kindled group. In kindled animals significant cell loss in CA1 of the dorsal hippocampus was found and this was efficaciously counteracted by Ena. However, Ena alone did induce similar cell loss compared to kindled animals. It is hypothesised that the effects of enadoline are mainly due to interferences with glutamatergic systems. |
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Authors:
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A Becker; H Braun; H Schröder; G Grecksch; V Höllt |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Brain research Volume: 823 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1999 Mar |
Date Detail:
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Created Date: 1999-05-07 Completed Date: 1999-05-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 191-7 Citation Subset: IM |
Copyright Information:
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Copyright 1999 Elsevier Science B.V. |
Affiliation:
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O.-v.-Guericke University, Faculty of Medicine, Institute of Pharmacology and Toxicology, Leipzigerstr. 44, D-39120, Magdeburg, Germany. axel.becker@medizin.uni-magdeburg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Benzofurans / pharmacology* Convulsants / pharmacology* Glutamic Acid / metabolism Hippocampus / drug effects*, metabolism, pathology* Kindling, Neurologic / drug effects* Learning / drug effects* Male Pentylenetetrazole / pharmacology* Pyrrolidines / pharmacology* Rats Rats, Wistar Seizures / chemically induced, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Benzofurans; 0/Convulsants; 0/Pyrrolidines; 107431-28-7/enadoline; 54-95-5/Pentylenetetrazole; 56-86-0/Glutamic Acid |
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