Document Detail

Effects of emboli, positive-pressure ventilation, and airway water on lung water measurements.
MedLine Citation:
PMID:  2457009     Owner:  NLM     Status:  MEDLINE    
We tested the effects of microemboli, continuous positive-pressure ventilation (CPPV), and aspirated airway water on measurements of extravascular lung water by use of the technique of thermal indicator dilution (ETVL). A control group of dogs and a group of dogs in which dextran was infused created all levels of pulmonary edema. In an emboli group 0.125 g/kg of starch microemboli (63-74 micron diam) were infused. In groups with emboli and CPPV, starch emboli were infused and CPPV was then applied at 15 cmH2O. In an airway saline group measured amounts of saline were poured into the airway. In all groups postmortem pulmonary extravascular tissue weight (PETW) was determined and compared with the last ETVL. Emboli created an increased scatter when the last ETVL is compared with PETW because 1) blood trapped distal to emboli was included in the ETVL measurement, and/or 2) diffusion limitations for the thermal indicator were exceeded. Emboli and CPPV decreased ETVL/PETW. Airway saline (80 +/- 5%) was measured by ETVL. In conclusion, the ETVL technique is reliable in well-perfused lungs but loses accuracy in measuring lung water after emboli of any size or with large amounts of airway fluid.
W H Noble; J C Kay
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  65     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1988 Jul 
Date Detail:
Created Date:  1988-09-21     Completed Date:  1988-09-21     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  156-64     Citation Subset:  IM    
Department of Anaesthesia, St. Michael's Hospital, Ontario, Canada.
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MeSH Terms
Extracellular Space / analysis*
Lung / analysis*
Positive-Pressure Respiration*
Pulmonary Embolism / physiopathology*
Tidal Volume
Reg. No./Substance:

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