| Effects of elevated plasma noradrenaline concentration on the immune system in humans. | |
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MedLine Citation:
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PMID: 10052667 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was designed to test the hypothesis that elevated plasma noradrenaline concentrations contribute to the exercise-induced modulation of the activity and percentage of the natural killer (NK) cells, and the leucocyte concentration. In a single blind, controlled, cross-over study, eight healthy men had noradrenaline infused for 1 h and achieved plasma noradrenaline concentrations comparable (20-fold increment) to those previously observed in cycle ergometer exercise (75% of maximal oxygen uptake for 1 h). The noradrenaline infusion increased the unstimulated, the interleukin-2 and interferon-alpha stimulated NK cell activity, and the percentage of CD16+ cells. The natural lytic activity per CD16+ cell however, did not change. The concentration of neutrophils, lymphocytes and CD16+ cells increased during the infusion. The neutrophil concentration remained elevated 2 h after infusion, at which time the lymphocyte count was back to normal. These results are comparable with the effects in the exercise model, and it is suggested that the augmented plasma noradrenaline concentrations, seen during extreme exercise, may participate in the exercise-induced immune changes. |
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Authors:
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M Kappel; T D Poulsen; H Galbo; B K Pedersen |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of applied physiology and occupational physiology Volume: 79 ISSN: 0301-5548 ISO Abbreviation: Eur J Appl Physiol Occup Physiol Publication Date: 1998 Dec |
Date Detail:
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Created Date: 1999-05-07 Completed Date: 1999-05-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0410266 Medline TA: Eur J Appl Physiol Occup Physiol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 93-8 Citation Subset: IM |
Affiliation:
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The Copenhagen Muscle Research Centre, Rigshospitalet, National University Hospital, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Agonists
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blood,
pharmacology* Adult Epinephrine / blood, pharmacology Exercise / physiology Exercise Test Humans Immune System / physiology* Interferon-alpha / metabolism Interleukin-2 / blood Killer Cells, Natural / immunology, metabolism, physiology Lymphocyte Count / drug effects Male Norepinephrine / blood, pharmacology* Receptors, IgG / immunology Single-Blind Method |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Agonists; 0/Interferon-alpha; 0/Interleukin-2; 0/Receptors, IgG; 51-41-2/Norepinephrine; 51-43-4/Epinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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