Document Detail

Effects of elevated plasma adrenaline levels on substrate metabolism, effort perception and muscle activation during low-to-moderate intensity exercise.
MedLine Citation:
PMID:  16215769     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to differentiate the role of raised plasma adrenaline (Adr) concentrations from sympathoadrenal activation associated with moderate-intensity exercise, on muscle activation, cardiopulmonary responses, fuel metabolism, and ratings of perceived exertion (RPE) during low-intensity exercise. Two groups of subjects (MOD, n=6; LOW, n=7) cycled on two occasions for 90 min. MOD cycled at 68% VO(2max) with saline infusion, and at 34% VO(2max) with Adr infusion. LOW cycled twice at 34% VO(2max), with either Adr or saline infusion. Infusions (0.015 g Adr/kg/min) started at 15 min and increased plasma [Adr] somewhat higher than during exercise at 68% VO(2max) (approximately 1.9 vs. 1.4 nM, at 75 min). Mean plasma glucose and lactate concentrations during LOW were significantly higher with Adr than saline infusion (5.1+/-0.6 vs. 4.4+/-0.3 mmol/l, P<0.01 and 2.1+/-0.8 vs. 1.3+/-0.5 mmol/l, P<0.01, respectively). Elevated [Adr], without increased exercise intensity, did not alter glycogenolysis. There were also no effects of Adr infusion at 34% VO(2max) on heart rate, oxygen consumption, [FFA], respiratory exchange ratio, intramuscular triglyceride utilization, muscle activation or RPE. In conclusion, elevated [Adr] similar to those found during moderate-intensity exercise increased plasma glucose and lactate availability, but did not alter intramuscular fuel utilization, effort perception or muscle activation.
Sacha J West; Julia H Goedecke; Lizl van Niekerk; Malcolm Collins; Alan St Clair Gibson; Ian A Macdonald; Timothy D Noakes; Estelle V Lambert
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-10-08
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  451     ISSN:  1432-2013     ISO Abbreviation:  Pflugers Arch.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-02-13     Completed Date:  2009-07-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  727-37     Citation Subset:  IM    
Department of Human Biology, UCT/MRC Research Unit for Exercise Science and Sports Medicine, University of Cape Town, P.O. Box 115, 7725 Newlands, South Africa.
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MeSH Terms
Blood Glucose
Epinephrine / blood*,  pharmacology*
Exercise / physiology*
Glucose / metabolism
Glycogen / metabolism
Heart Rate
Muscle, Skeletal / physiology*
Norepinephrine / blood,  metabolism
Pulmonary Gas Exchange
Sympathomimetics / blood*,  pharmacology*
Triglycerides / metabolism
Young Adult
Reg. No./Substance:
0/Blood Glucose; 0/Sympathomimetics; 0/Triglycerides; 50-99-7/Glucose; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 9005-79-2/Glycogen

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