| Effects of electroconvulsive therapy on hypothalamic-pituitary-thyroid axis activity in depressed patients. | |
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MedLine Citation:
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PMID: 12452542 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study, the authors aimed to test the hypothesis that electroconvulsive therapy (ECT) may cause some alterations in hypothalamic-pituitary-thyroid (HPT) axis hormones and these responses may change throughout respective ECT sessions. Nineteen depressed inpatients (8 males, 11 females; mean age+/-S.D.: 44.77+/-10.59 years) considered suitable for ECT were included in the study. Each patient was exposed to 7 ECT sessions with general anaesthesia. The blood samples for measurements of thyroid-stimulating hormone (TSH), free thyroiodothyronine (fT3) and free thyroxine (fT4) were drawn before (baseline) and after propofol, immediately after ECT, and 30 and 60 min after ECT during the first and last (seventh) ECTs. In both the first and seventh ECTs, there was a significant increase in TSH levels 30 min after ECT compared to the pre-ECT values. Additionally, a significant decrease in post-ECT fT4 values compared to the baseline values was found only during the seventh ECT. No difference was detected in the TSH, fT3 and fT4 responses to ECT between males and females, and between bipolar and unipolar depressive patients. These results show that ECT may have some effects on the HPT system. However, whether there is a relationship between these neuroendocrine responses and the therapeutic effect of ECT is not clear. |
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Authors:
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Ertugrul Esel; Tayfun Turan; Mustafa Kula; Mustafa Reyhancan; Ali Gonul; Mustafa Basturk; Seher Sofuoglu |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Progress in neuro-psychopharmacology & biological psychiatry Volume: 26 ISSN: 0278-5846 ISO Abbreviation: Prog. Neuropsychopharmacol. Biol. Psychiatry Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2002-11-27 Completed Date: 2003-03-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8211617 Medline TA: Prog Neuropsychopharmacol Biol Psychiatry Country: England |
Other Details:
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Languages: eng Pagination: 1171-5 Citation Subset: IM |
Affiliation:
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Erciyes University School of Medicine, Department of Psychiatry, Talas Road, 38039 Kayseri, Turkey. ertugrulesel@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Bipolar Disorder / physiopathology, psychology, therapy Depressive Disorder / physiopathology*, psychology, therapy* Depressive Disorder, Major / physiopathology, psychology, therapy Electroconvulsive Therapy* Female Humans Hypothalamo-Hypophyseal System / physiopathology* Male Middle Aged Pituitary Gland / physiopathology* Psychiatric Status Rating Scales Radioimmunoassay Thyroid Gland / physiopathology* Thyroid Hormones / blood |
| Chemical | |
Reg. No./Substance:
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0/Thyroid Hormones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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