| Effects of electroacupuncture Zusanli (ST36) on food intake and expression of POMC and TRPV1 through afferents-medulla pathway in Obese Prone Rats. | |
| | |
MedLine Citation:
|
PMID: 23116614 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE: The purpose of this study was to determine the effects of electroacupuncture (EA) ST36 on food intake and body weight in Obese Prone (OP) rats compared to obese resistant (OR) strain on a high fat diet. The influences of EA on mRNA levels of pro-opiomelanocortin (POMC), transient receptor potential vanilloid type-1 (TRPV1), and neuronal nitric oxide synthase (nNOS) were also examined in the medulla regions and ST36 skin tissue. METHODS: Advanced EA ST36 was conducted in two sessions of 20min separated by an 80min interval for 7 days. Food intake and body weight were recorded in conscious rats every day. Real time PCR was conducted in the micropunches of the medulla regions and skin tissues at the end of the treatment. RESULTS: Food intake and body weight were significantly reduced by advanced EA ST36 in OP rats, but slightly decreased in OR strain and sham-EA rats. Advanced EA ST36 produced a marked increase in POMC mRNA level in the nucleus tractus solitarius (NTS) and hypoglossal nucleus (HN) regions. TRPV1 and nNOS mRNAs were simultaneously increased in the NTS/gracile nucleus regions and in the ST36 skin regions by the EA treatment in OP rats. CONCLUSIONS: We conclude that advanced EA ST36 produces an up-regulation of anorexigenic factor POMC production in the NTS/HN, which inhibits food intake and reduces body weight. EA-induced expression of TRPV1-nNOS in the ST36 and the NTS/gracile nucleus is involved in the signal transduction of EA stimuli via somatosensory afferents-medulla pathways. |
| | |
Authors:
|
Bo Ji; Jay Hu; Shengxing Ma |
Related Documents
:
|
22821834 - American journal of medical genetics part a: volume 158a, number 8, august 2012. 22370534 - Changes in prevalence and characteristics of ige-mediated food allergies in children re... 9017724 - Performance on the purdue pegboard and finger tapping by schizophrenics after mellow an... 21236394 - Infectious complications associated with immunomodulating biologic agents. 22054184 - Evaluation of murine norovirus persistence in environments relevant to food production ... 17661924 - Mite and pet allergen exposure in hotels in uberlândia, midwestern brazil. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-10-29 |
Journal Detail:
|
Title: Peptides Volume: - ISSN: 1873-5169 ISO Abbreviation: Peptides Publication Date: 2012 Oct |
Date Detail:
|
Created Date: 2012-11-2 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8008690 Medline TA: Peptides Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012. Published by Elsevier Inc. |
Affiliation:
|
Department of Obstetrics and Gynecology, David Geffen School of Medicine at University of California at Los Angeles, the Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The human glucagon-like peptide-1 analogue liraglutide regulates pancreatic beta-cell proliferation ...
Next Document: Influence of dyeing auxiliaries on AB74 dye degradation by UV/H(2)O(2) process.