Document Detail

Effects of electroacupuncture Zusanli (ST36) on food intake and expression of POMC and TRPV1 through afferents-medulla pathway in obese prone rats.
MedLine Citation:
PMID:  23116614     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to determine the effects of electroacupuncture (EA) ST36 on food intake and body weight in obese prone (OP) rats compared to obese resistant (OR) strain on a high fat diet. The influences of EA on mRNA levels of pro-opiomelanocortin (POMC), transient receptor potential vanilloid type-1 (TRPV1), and neuronal nitric oxide synthase (nNOS) were also examined in the medulla regions and ST36 skin tissue.
METHODS: Advanced EA ST36 was conducted in two sessions of 20 min separated by an 80 min interval for 7 days. Food intake and body weight were recorded in conscious rats every day. Real time PCR was conducted in the micropunches of the medulla regions and skin tissues at the end of the treatment.
RESULTS: Food intake and body weight were significantly reduced by advanced EA ST36 in OP rats, but slightly decreased in OR strain and sham-EA rats. Advanced EA ST36 produced a marked increase in POMC mRNA level in the nucleus tractus solitarius (NTS) and hypoglossal nucleus (HN) regions. TRPV1 and nNOS mRNAs were simultaneously increased in the NTS/gracile nucleus regions and in the ST36 skin regions by the EA treatment in OP rats.
CONCLUSIONS: We conclude that advanced EA ST36 produces an up-regulation of anorexigenic factor POMC production in the NTS/HN, which inhibits food intake and reduces body weight. EA-induced expression of TRPV1-nNOS in the ST36 and the NTS/gracile nucleus is involved in the signal transduction of EA stimuli via somatosensory afferents-medulla pathways.
Bo Ji; Jay Hu; Shengxing Ma
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-10-29
Journal Detail:
Title:  Peptides     Volume:  40     ISSN:  1873-5169     ISO Abbreviation:  Peptides     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-05-06     Completed Date:  2014-01-07     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  United States    
Other Details:
Languages:  eng     Pagination:  188-94     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Afferent Pathways / metabolism*
Body Weight
Gene Expression Regulation
Nitric Oxide Synthase / metabolism
Obesity / genetics,  therapy*
Pro-Opiomelanocortin / metabolism*
TRPV Cation Channels / metabolism
Grant Support
Reg. No./Substance:
0/TRPV Cation Channels; 0/Trpv1 protein, rat; 66796-54-1/Pro-Opiomelanocortin; EC Oxide Synthase

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