Document Detail

Effects of electro-acupuncture on the expression of c-jun and c-fos in spared dorsal root ganglion and associated spinal laminae following removal of adjacent dorsal root ganglia in cats.
MedLine Citation:
PMID:  16730915     Owner:  NLM     Status:  MEDLINE    
This study evaluated the plastic changes of c-jun and c-fos in the right sixth lumbar dorsal root ganglion (L6 DRG), Rexed's lamina II in representative spinal segments L3, L5, and L6 and in the nucleus dorsalis (ND) at L3 segments after electro-acupuncture (EA) in cats subjected to removal of L1-L5 and L7-S2 DRG. Following dorsal root ganglionectomy, there was a significant increase in the density of c-jun immunoreactivity in the neurons and glia in spinal lamina II and in the ND; there was also marked elevation in the expression of c-fos in ND. In both cases there was no change in the c-jun and c-fos immunoreactivity in the DRG. After EA in the operated animals, there was an up-regulation in the expression of c-jun in the L6 DRG and the associated spinal lamina II; however, increased c-fos expression was detected only in the L6 DRG. Western blot and RT-PCR were also performed to quantitatively explore the mRNA and protein expression changes in the spinal dorsal horn and associated DRG. Following partial deafferentation, there was a significant increase in the protein level of both c-jun and c-fos in the dorsal horn, while, in both cases there was no change in c-jun and c-fos protein and mRNA in the DRG. After EA in the operated animals, both c-jun protein and its mRNA in the L6 DRG as well as the associated dorsal horn of L6 spinal segment were upregulated, but increased c-fos protein and its mRNA was observed only in the L6 DRG. These findings suggested that c-jun and c-fos might be related to the acupuncture promoted spinal cord plasticity as reported previously.
T T-H Wang; W-L Yuan; Q Ke; X-B Song; X Zhou; Y Kang; H-T Zhang; Y Lin; Y-L Hu; Z-T Feng; L L-Y Wu; X-F Zhou
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2006-05-30
Journal Detail:
Title:  Neuroscience     Volume:  140     ISSN:  0306-4522     ISO Abbreviation:  Neuroscience     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-07-03     Completed Date:  2006-10-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1169-76     Citation Subset:  IM    
Institute for Research on Neuroscience, Kunming Medical College, No. 191 Renming West Road, Kunming 650031, China.
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MeSH Terms
Electroacupuncture / methods*
Ganglia, Spinal / injuries,  metabolism*
Gene Expression Regulation / physiology*
Genes, fos / physiology*
Genes, jun / physiology*
Neuronal Plasticity / physiology
Posterior Horn Cells / cytology,  metabolism*
Spinal Cord / cytology,  metabolism
Up-Regulation / physiology

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