Document Detail

Effects of elastic loading and exercise on pulmonary gas exchange in dogs.
MedLine Citation:
PMID:  1750036     Owner:  NLM     Status:  MEDLINE    
We assessed the effects of negative intrathoracic pressure induced by inspiratory elastic loading on pulmonary, gas exchange with and without electrically induced hindlimb exercise in 8 normal, anesthetized dogs. Two elastic loads (EL) were used; one of 81 and one of 140 cmH2O/liter. These are equivalent to doubling and tripling the normal elastance of the dog's respiratory system, respectively. Elastic loading decreased ventilation and caused hypoxemia and hypercapnia, but it did not affect systemic arterial pressure or heart rate. During exercise, increase in ventilation was limited, whereas increase in cardiac output was not affected by elastic loading. Alveolar-arterial O2 tension difference (A-aDO2) was not changed significantly by exercise alone. However, elastic loading accompanied by exercise increased A-aDO2. Although comparable end-inspiratory pleural pressure was achieved with large EL (-29 +/- 2 cmH2O, mean +/- SE) and small EL with exercise (-30 +/- 2 cmH2O), the latter increased A-aDO2 whereas the former did not. Large negative intrapleural pressure combined with increased cardiac output may have caused transient interstitial edema.
T Chonan; W Hida; Y Kikuchi; C Shindoh; O Taguchi; H Miki; T Takishima
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Tohoku journal of experimental medicine     Volume:  164     ISSN:  0040-8727     ISO Abbreviation:  Tohoku J. Exp. Med.     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1992-01-17     Completed Date:  1992-01-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0417355     Medline TA:  Tohoku J Exp Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  157-67     Citation Subset:  IM; S    
First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
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MeSH Terms
Carbon Dioxide / blood
Cardiac Output / physiology
Hemodynamics / physiology
Hindlimb / physiology
Muscle Contraction / drug effects
Oxygen Consumption / physiology
Physical Exertion / physiology*
Pulmonary Gas Exchange / physiology*
Respiratory Function Tests
Reg. No./Substance:
124-38-9/Carbon Dioxide

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