Document Detail

Effects of eicosapentaenoic acid and vitamin C on glycemic indices, blood pressure, and serum lipids in type 2 diabetic Iranian males.
MedLine Citation:
PMID:  22247720     Owner:  NLM     Status:  PubMed-not-MEDLINE    
BACKGROUND: Eicosapentaenoic acid (EPA) is the principal ω-3 fatty acids in marine oils. Fasting blood sugar (FBS), HbA1c and some of the plasma lipids and lipoproteins has been negatively related to the intake of ω-3 fatty acids and ascorbic acid, in some studies. Therefore, the purpose of this study was to assess the effects of EPA and/or vitamin C on glycemic indices, blood pressure, and plasma lipids in type 2 diabetic Iranian males.
METHODS: Sixty five men with type 2 diabetes were enrolled into the study between April 2 and June 27, 2008. Venous blood samples were obtained from all participants after 10 hours of fasting, at the baseline and after the intervention. Subjects received 500 mg EPA and/or 200 mg vitamin C and/or placebo depending on their groups. For eight weeks, 15 participants received EPA supplements with vitamin C (group 1), 16 took EPA supplements and vitamin C placebo (group 2), 17 took EPA placebo and vitamin C (group 3), and 17 received EPA placebo and vitamin C placebo (group 4), daily.
RESULTS: There were significant decreases in FBS, HbA1C, LDL-C and TG in groups 1, 2, 3 and 4 (p < 0.01), but significant decreases in TC were shown only in groups 1, 2 and 3 (p < 0.01). There was a significant increase in HDL-C in all groups (p < 0.01).
CONCLUSIONS: In summary, it is concluded that, eight weeks of taking EPA + vitamin C supplementation improved the plasma levels of cardiovascular markers but didn't reduce BP.
Mohammad Mehdi Shakouri Mahmoudabadi; Mahmoud Djalali; Seyed Abolghassem Djazayery; Seyed Ali Keshavarz; Mohammad Reza Eshraghian; Ali Akbar Saboor Yaraghi; Gholamreza Askari; Reza Ghiasvand; Mahnaz Zarei
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences     Volume:  16 Suppl 1     ISSN:  1735-7136     ISO Abbreviation:  J Res Med Sci     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2012-01-16     Completed Date:  2012-10-02     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101235599     Medline TA:  J Res Med Sci     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  S361-7     Citation Subset:  -    
Department of Nutrition and Biochemistry, School of Public Health, Institute of Public Health Research, Tehran University of Medical Sciences, Tehran, Iran.
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