Document Detail

Effects of echinocytosis on hemorrheologic values and exercise performance in horses.
MedLine Citation:
PMID:  8172408     Owner:  NLM     Status:  MEDLINE    
Effects of echinocytosis on blood rheology and exercise performance were evaluated for 5 Thoroughbreds. Echinocytosis was induced by administration of furosemide (1 mg/kg of body weight, IM, q 12 h) for 4 days. Furosemide treatment resulted in decreases in serum sodium and serum chloride concentrations and in RBC chloride and potassium concentrations. Echinocytosis was associated with increased RBC density as determined by RBC density gradient centrifugation. However, samples containing echinocytes were more filterable than control samples, indicating that echinocytes were not rigid cells. Erythrocyte sedimentation rate was decreased in blood samples containing echinocytes, indicating that cell-to-cell interaction was reduced. Whole blood viscosity was not altered by presence of echinocytes. Echinocytes did not impair the capacity of horses to complete treadmill exercise tests, nor did they alter heart rate or blood gas variables. However, plasma lactate concentration was higher in samples obtained during exercise at a treadmill speed of 9 m/s. Echinocytosis was associated with higher postrace creatine kinase activity. These data indicate that echinocytes may be dense, but not rigid cells, which have decreased tendency to aggregate and do not increase whole blood viscosity. Therefore, echinocytes are unlikely to inhibit or obstruct microvascular blood flow.
D J Weiss; R J Geor; C M Smith
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of veterinary research     Volume:  55     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-06-02     Completed Date:  1994-06-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  204-10     Citation Subset:  IM    
Department of Veterinary Pathobiology, University of Minnesota, St Paul 55108.
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MeSH Terms
Blood Sedimentation
Blood Viscosity*
Chlorides / blood
Erythrocyte Count
Erythrocytes / drug effects,  pathology,  physiology*
Hematologic Diseases / blood,  chemically induced,  veterinary*
Horse Diseases*
Horses / blood*
Physical Conditioning, Animal*
Physical Exertion*
Potassium / blood
Reference Values
Sodium / blood
Reg. No./Substance:
0/Chlorides; 54-31-9/Furosemide; 7440-09-7/Potassium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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