| Effects of ebelactone B, a lipase inhibitor, on intestinal fat absorption in the rat. | |
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MedLine Citation:
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PMID: 8835930 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ebelactones A and B, natural products from Streptomyces aburaviensis are potent inhibitors of pancreatic lipase. Lipase is the key enzyme required for the absorption of dietary triglycerides (TG). Ebelactone B inhibited, in a dose-dependent manner, the intestinal absorption of fat after fat-feeding in the rat. The most effective inhibition was observed when the inhibitor was administered at 60 min prior to fat-feeding. When ebelactone B (10 mg/kg) was administered, the serum levels of TG (58%) and cholesterol (36%) were decreased. Since ebelactone B effectively inhibitors absorption of dietary fat, if may provide a promising means for prophylaxis or therapeutics of hyperlipidemia and obesity. |
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Authors:
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Y Nonaka; H Ohtaki; E Ohtsuka; T Kocha; T Fukuda; T Takeuchi; T Aoyagi |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of enzyme inhibition Volume: 10 ISSN: 8755-5093 ISO Abbreviation: J. Enzym. Inhib. Publication Date: 1996 |
Date Detail:
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Created Date: 1997-03-03 Completed Date: 1997-03-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8709734 Medline TA: J Enzyme Inhib Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 57-63 Citation Subset: IM |
Affiliation:
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Showa College of Pharmaceutical Science, Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cholesterol / blood Diet Esterases / antagonists & inhibitors Hydrogen-Ion Concentration Intestinal Absorption / drug effects* Lactones / pharmacology Lipase / antagonists & inhibitors*, blood Lipoproteins / blood Male Molecular Structure Pancreas / enzymology Rats Rats, Sprague-Dawley Time Factors Triglycerides / blood, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Lactones; 0/Lipoproteins; 0/Triglycerides; 57-88-5/Cholesterol; 76808-15-6/ebelactone B; 76808-16-7/ebelactone A; EC 3.1.-/Esterases; EC 3.1.1.3/Lipase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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