Document Detail


Effects of early undernutrition on kinetic parameters of brain acetylcholinesterase from adult rats.
MedLine Citation:
PMID:  8249659     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of undernutrition during early life on acetylcholinesterase (AChE) specific activity of cerebellum, hippocampus, hypothalamus and striatum were examined in rehabilitated adults rats. Undernourished rats were raised by dams maintained on a restricted food scheme from pup birth to pup weaning (day 31). The offspring were maintained on a restricted food schedule until day 38 when they started to have free access to food until 70-80 days of age. Control rats were raised by dams which had free access to food. The results showed that early malnutrition caused a significant increase in AChE specific activity in cerebellum (about 20%), striatum (about 40%), and hypothalamus (about 30%). No changes were found in the hippocampus. Undernutrition caused a significant increase in Vmax when compared to the control group without changes in Km both in cerebellum and striatum. These results suggest that early undernutrition changes AChE concentration in cerebellum and striatum and does not affect the affinity of the enzyme for the substrate.
Authors:
J B Rocha; T Emanuelli; M E Pereira
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta neurobiologiae experimentalis     Volume:  53     ISSN:  0065-1400     ISO Abbreviation:  Acta Neurobiol Exp (Wars)     Publication Date:  1993  
Date Detail:
Created Date:  1993-12-27     Completed Date:  1993-12-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1246675     Medline TA:  Acta Neurobiol Exp (Wars)     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  431-7     Citation Subset:  IM    
Affiliation:
Setor de Bioquimica, Universidade Federal de Santa Maria, Brasil.
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MeSH Terms
Descriptor/Qualifier:
Acetylcholinesterase / metabolism*
Animals
Brain / enzymology*
Female
Kinetics
Male
Nutrition Disorders / enzymology*
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
EC 3.1.1.7/Acetylcholinesterase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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