Document Detail

Effects of early undernutrition on hippocampal development and function.
MedLine Citation:
PMID:  7123005     Owner:  NLM     Status:  MEDLINE    
The possibility of a "hippocampal syndrome' was investigated in mature animals whose mothers had received a period of undernutrition during pregnancy and throughout lactation. Spontaneous alternation behaviour was abolished, and performance was found to be at chance level. Significant depletions in cell numbers were found throughout the hippocampal region; however, hippocampal theta rhythm remained and threshold levels for theta driving appeared normal. It was concluded that the behavioural differences observed did no arise from some simple deficit in the circuitry controlling hippocampal theta rhythm and that it was more likely due to an impairment at the synaptic level. The similarity of these, and other recent behavioural observations, to those of animals with hippocampal damage may provide a reasonable basis for investigating a number of learning deficits induced by early undernutrition.
T C Jordan; K F Howells; N McNaughton; P L Heatlie
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Research in experimental medicine. Zeitschrift für die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie     Volume:  180     ISSN:  0300-9130     ISO Abbreviation:  Res Exp Med (Berl)     Publication Date:  1982  
Date Detail:
Created Date:  1982-12-02     Completed Date:  1982-12-02     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0324736     Medline TA:  Res Exp Med (Berl)     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  201-7     Citation Subset:  IM    
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MeSH Terms
Behavior, Animal
Cell Count
Hippocampus / growth & development*,  physiology
Nutrition Disorders / complications*

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