Document Detail

Effects of early statin treatment on symptomatic heart failure and ischemic events after acute myocardial infarction in Japanese.
MedLine Citation:
PMID:  16616020     Owner:  NLM     Status:  MEDLINE    
Statins have been shown to prevent coronary artery disease and to preserve left ventricular function in dilated cardiomyopathy. We hypothesized that early use of statins would decrease cardiovascular events, including heart failure in patients with acute myocardial infarction (AMI). To examine the effect of statins in Japanese patients with AMI, a prospective, randomized, open-label trial was conducted in 486 patients with normal total cholesterol levels. Patients were randomly assigned to receive any available statin (n = 241) within 96 hours of AMI onset or no statin (n = 245) and were followed for up to 24 months. The primary end point was a composite of cardiovascular death, nonfatal AMI, recurrent symptomatic myocardial ischemia, congestive heart failure, and stroke. Event rate for the primary end point was lower in the statin group than in the nonstatin group (6.1% vs 11.4%, p = 0.0433). The statin group had a lower risk of congestive heart failure and symptomatic myocardial ischemia (p = 0.0154 and 0.0264, respectively). In conclusion, early lipid-lowering therapy with statins decreases recurrent cardiovascular events, in particular, congestive heart failure.
Tomohiro Sakamoto; Sunao Kojima; Hisao Ogawa; Hideki Shimomura; Kazuo Kimura; Yasuhiro Ogata; Naritsugu Sakaino; Akira Kitagawa;
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2006-03-10
Journal Detail:
Title:  The American journal of cardiology     Volume:  97     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-17     Completed Date:  2006-06-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1165-71     Citation Subset:  AIM; IM    
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
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MeSH Terms
Angina, Unstable / epidemiology,  prevention & control*
Angioplasty, Transluminal, Percutaneous Coronary
Asian Continental Ancestry Group
C-Reactive Protein / analysis
Cholesterol / blood
Follow-Up Studies
Heart Failure / epidemiology,  prevention & control*
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
Japan / epidemiology
Middle Aged
Myocardial Infarction / therapy*
Patient Readmission
Prospective Studies
Thrombolytic Therapy
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 57-88-5/Cholesterol; 9007-41-4/C-Reactive Protein

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