Document Detail


Effects of early rearing environment on immune responses of infant rhesus monkeys.
MedLine Citation:
PMID:  7620209     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In animals, perturbations of the rearing environment have been shown to alter behavior, cognition, and physiology, including immune responses. In order to evaluate the effect of early rearing conditions on the development of immune responses in the infant primate, several immunological measures were assessed in rhesus monkey infants, nursery-reared (NR) or mother-reared (MR), from birth to 2 years of age. Rearing in the absence of the mother affected several aspects of cellular immunity. NR monkeys had significantly lower proportions of CD8 cells and lower natural killer cell activity than did MR monkeys. In contrast, their lymphocyte proliferation responses to mitogen stimulation were higher than those of MR monkeys. An attempt to behaviorally rehabilitate the NR infants at 1 year of age did not result in a recovery of normal immune responses. This study indicates that abnormal early rearing may have long-lasting effects on the immune system, which could have health consequences later in life.
Authors:
G R Lubach; C L Coe; W B Ershler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain, behavior, and immunity     Volume:  9     ISSN:  0889-1591     ISO Abbreviation:  Brain Behav. Immun.     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-08-31     Completed Date:  1995-08-31     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8800478     Medline TA:  Brain Behav Immun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  31-46     Citation Subset:  IM    
Affiliation:
Wisconsin Regional Primate Research Center, University of Wisconsin, Madison 53706, USA.
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MeSH Terms
Descriptor/Qualifier:
Animal Husbandry
Animals
Antibodies, Bacterial / biosynthesis
Antibodies, Viral / biosynthesis
Female
Hydrocortisone / blood
Immunity, Cellular
Immunity, Maternally-Acquired
Immunologic Deficiency Syndromes / etiology*,  psychology
Killer Cells, Natural / immunology
Lymphocyte Activation
Lymphocyte Count
Macaca mulatta / immunology*,  psychology
Male
Maternal Behavior
Maternal Deprivation*
Mental Disorders / etiology
Psychoneuroimmunology
Stress, Psychological / immunology
T-Lymphocyte Subsets
Vaccination
Grant Support
ID/Acronym/Agency:
MH41659/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Antibodies, Viral; 50-23-7/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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