| Effects of early rearing environment on immune responses of infant rhesus monkeys. | |
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MedLine Citation:
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PMID: 7620209 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In animals, perturbations of the rearing environment have been shown to alter behavior, cognition, and physiology, including immune responses. In order to evaluate the effect of early rearing conditions on the development of immune responses in the infant primate, several immunological measures were assessed in rhesus monkey infants, nursery-reared (NR) or mother-reared (MR), from birth to 2 years of age. Rearing in the absence of the mother affected several aspects of cellular immunity. NR monkeys had significantly lower proportions of CD8 cells and lower natural killer cell activity than did MR monkeys. In contrast, their lymphocyte proliferation responses to mitogen stimulation were higher than those of MR monkeys. An attempt to behaviorally rehabilitate the NR infants at 1 year of age did not result in a recovery of normal immune responses. This study indicates that abnormal early rearing may have long-lasting effects on the immune system, which could have health consequences later in life. |
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Authors:
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G R Lubach; C L Coe; W B Ershler |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Brain, behavior, and immunity Volume: 9 ISSN: 0889-1591 ISO Abbreviation: Brain Behav. Immun. Publication Date: 1995 Mar |
Date Detail:
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Created Date: 1995-08-31 Completed Date: 1995-08-31 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8800478 Medline TA: Brain Behav Immun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 31-46 Citation Subset: IM |
Affiliation:
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Wisconsin Regional Primate Research Center, University of Wisconsin, Madison 53706, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animal Husbandry Animals Antibodies, Bacterial / biosynthesis Antibodies, Viral / biosynthesis Female Hydrocortisone / blood Immunity, Cellular Immunity, Maternally-Acquired Immunologic Deficiency Syndromes / etiology*, psychology Killer Cells, Natural / immunology Lymphocyte Activation Lymphocyte Count Macaca mulatta / immunology*, psychology Male Maternal Behavior Maternal Deprivation* Mental Disorders / etiology Psychoneuroimmunology Stress, Psychological / immunology T-Lymphocyte Subsets Vaccination |
| Grant Support | |
ID/Acronym/Agency:
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MH41659/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Bacterial; 0/Antibodies, Viral; 50-23-7/Hydrocortisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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