| Effects of early pregnancy loss on hormone levels in the subsequent menstrual cycle. | |
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MedLine Citation:
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PMID: 20504096 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous studies of hormone patterns after clinical miscarriage suggest reduced pituitary function. Hormonal effects of very early pregnancy loss (before 6 weeks gestation) have not been described. We used within-woman differences between menstrual cycles in urinary hormone measurements from women in the North Carolina Early Pregnancy Study to describe hormonal changes after very early pregnancy loss (n = 28 early losses; 80 non-conception comparison cycles). We found lower pre-ovulatory luteinising hormone and shorter luteal phase length after very early pregnancy loss, but the differences were non-significant (p > 0.3) and smaller than those reported in the spontaneous miscarriage literature. Consistent with the reduced pituitary function reported post-spontaneous miscarriage, we found a slower rate of oestrogen rise (p = 0.08). There was no evidence of lower mid-luteal steroid levels as has been suggested for post-spontaneous miscarriage cycles. Very early pregnancy losses do not appear to influence subsequent menstrual cycles to the same degree as spontaneous miscarriages. |
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Authors:
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Anne Marie Z Jukic; Clarice R Weinberg; Allen J Wilcox; Donna D Baird |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural Date: 2010-05-26 |
Journal Detail:
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Title: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology Volume: 26 ISSN: 1473-0766 ISO Abbreviation: Gynecol. Endocrinol. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-11 Completed Date: 2011-03-08 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 8807913 Medline TA: Gynecol Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 897-901 Citation Subset: IM |
Affiliation:
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Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. jukica@niehs.nih.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Spontaneous
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urine* Adult Chorionic Gonadotropin / urine* Estrone / urine* Female Humans Luteinizing Hormone / urine* Menstrual Cycle / urine* Pregnancy Pregnanediol / urine* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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Z99 ES999999/ES/NIEHS NIH HHS; ZIA ES044003-33/ES/NIEHS NIH HHS; ZIA ES045005-14/ES/NIEHS NIH HHS; ZIA ES049003-21/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin; 26445-07-8/Pregnanediol; 53-16-7/Estrone; 9002-67-9/Luteinizing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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