Document Detail


Effects of early pregnancy loss on hormone levels in the subsequent menstrual cycle.
MedLine Citation:
PMID:  20504096     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previous studies of hormone patterns after clinical miscarriage suggest reduced pituitary function. Hormonal effects of very early pregnancy loss (before 6 weeks gestation) have not been described. We used within-woman differences between menstrual cycles in urinary hormone measurements from women in the North Carolina Early Pregnancy Study to describe hormonal changes after very early pregnancy loss (n = 28 early losses; 80 non-conception comparison cycles). We found lower pre-ovulatory luteinising hormone and shorter luteal phase length after very early pregnancy loss, but the differences were non-significant (p > 0.3) and smaller than those reported in the spontaneous miscarriage literature. Consistent with the reduced pituitary function reported post-spontaneous miscarriage, we found a slower rate of oestrogen rise (p = 0.08). There was no evidence of lower mid-luteal steroid levels as has been suggested for post-spontaneous miscarriage cycles. Very early pregnancy losses do not appear to influence subsequent menstrual cycles to the same degree as spontaneous miscarriages.
Authors:
Anne Marie Z Jukic; Clarice R Weinberg; Allen J Wilcox; Donna D Baird
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural     Date:  2010-05-26
Journal Detail:
Title:  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology     Volume:  26     ISSN:  1473-0766     ISO Abbreviation:  Gynecol. Endocrinol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-11     Completed Date:  2011-03-08     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  8807913     Medline TA:  Gynecol Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  897-901     Citation Subset:  IM    
Affiliation:
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. jukica@niehs.nih.gov
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MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / urine*
Adult
Chorionic Gonadotropin / urine*
Estrone / urine*
Female
Humans
Luteinizing Hormone / urine*
Menstrual Cycle / urine*
Pregnancy
Pregnanediol / urine*
Young Adult
Grant Support
ID/Acronym/Agency:
Z99 ES999999/ES/NIEHS NIH HHS; ZIA ES044003-33/ES/NIEHS NIH HHS; ZIA ES045005-14/ES/NIEHS NIH HHS; ZIA ES049003-21/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Chorionic Gonadotropin; 26445-07-8/Pregnanediol; 53-16-7/Estrone; 9002-67-9/Luteinizing Hormone
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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