| Effects of early nutrition intervention on IGF1, IGFBP3, intestinal development, and catch-up growth of intrauterine growth retardation rats. | |
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MedLine Citation:
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PMID: 15506645 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the effects of early nutritional intervention on the serum insulin-like growth factor-1 (IGF1), insulin-like growth factor binding protein 3 (IGFBP3), intestinal development, and catch-up growth of intrauterine growth retardation (IUGR) rats by giving the IUGR new born rats different protein level diet. METHODS: IUGR rat model was built by starvation of pregnant female rats. Twenty-four IUGR pups and 8 normal pups were divided randomly into 4 groups: normal control group (C group); IUGR control group (S group), IUGR low-protein diet group (SL group), and IUGR high-protein diet group (SH group). Detected the serum IGF1, IGFBP3, body weight, body length, intestinal weight length, intestinal villi height (VH), crypt depth (CD), villi absorbing area (VSA), mucous thickness (MT), and disaccharidase at the 4th week. RESULTS: (1) The SH group showed the fastest catch-up growth, serum IGF1, IGFBP3, VH, and VSA were significantly higher than those of normal control group and IUGR control group. The intestinal weight and length, and the activities of lactase and saccharase of the SH group also reached the normal control group level. (2) The SL group kept on small size, the serum IGF1, IGFBP3, and most of intestinal histological indexes were all significantly lower than other groups. (3) IGF1, IGFBP3 were positively correlated to intestinal VH, VSA, saccharase, body weight and length. CONCLUSIONS: The serum IGF1 was a sensitive index to the catch-up growth. The early nutritional intervention of high-protein diet after birth is helpful for the catch-up growth of IUGR through promoting the intestinal development and the absorption of nutrition. |
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Authors:
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Xiao-shan Qiu; Ting-ting Huang; Hui-ying Deng; Zhen-yu Shen; Zhi-yong Ke; Kai-yong Mei; Feng Lai |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Chinese medical sciences journal = Chung-kuo i hsüeh k'o hsüeh tsa chih / Chinese Academy of Medical Sciences Volume: 19 ISSN: 1001-9294 ISO Abbreviation: Chin. Med. Sci. J. Publication Date: 2004 Sep |
Date Detail:
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Created Date: 2004-10-27 Completed Date: 2004-12-29 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9112559 Medline TA: Chin Med Sci J Country: China |
Other Details:
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Languages: eng Pagination: 189-92 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn / growth & development* Body Weight / drug effects Dietary Proteins / pharmacology* Female Fetal Growth Retardation / blood*, etiology Insulin-Like Growth Factor Binding Protein 3 / blood* Insulin-Like Growth Factor I / metabolism* Intestines / growth & development, pathology Nutritional Physiological Phenomena* Pregnancy Random Allocation Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Dietary Proteins; 0/Insulin-Like Growth Factor Binding Protein 3; 67763-96-6/Insulin-Like Growth Factor I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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