Document Detail

Effects of early and late-gestational maternal stress and synthetic glucocorticoid on development of the fetal hypothalamus-pituitary-adrenal axis in sheep.
MedLine Citation:
PMID:  22512268     Owner:  NLM     Status:  Publisher    
Prenatal maternal stress (PMS) programs dysregulation of the hypothalamus-pituitary-adrenal axis (HPAA) in postnatal life, though time periods vulnerable to PMS are still unclear. We evaluated in pregnant sheep the effect of PMS during early gestation (30 - 100 days, dGA; term is 150 dGA) or late gestation (100-120 dGA) on development of fetal HPAA function. We compared the effects of endogenous cortisol with synthetic glucocorticoid exposure, as used clinically to enhance fetal lung maturation. Pregnant sheep were exposed to repeated isolation stress twice per week for 3h in a separate box with no visual, tactile or auditory contact with their flock-mates either during early (n=7) or late (n=7) gestation. Additional groups received two courses of betamethasone (n=7; 2 x 110μ body weight 24h apart) during late gestation (106/107 and 112/113 dGA, n=7) or acted as controls (n=7). Fetal cortisol responses to hypotensive challenge, a physiological fetal stressor, were measured at 112 and 129 dGA, i.e. before and during maturation of the HPAA. Hypotension was induced by fetal infusion of sodium nitroprusside, a potent vasodilator. At 112 dGA, neither PMS nor betamethasone altered fetal cortisol responses. PMS during early or late gestation, and betamethasone treatment increased fetal cortisol responses at 129 dGA with the greatest increase achieved in stressed early pregnant sheep. Thus, development of the HPAA is vulnerable to inappropriate levels of glucocorticoids during long periods of fetal life, whereas early gestation is most vulnerable to PMS.
Florian Rakers; Vilmar Frauendorf; Sven Rupprecht; Rene Schiffner; Sabine Bischoff; Michael Kiehntopf; Petra Reinhold; Otto W Witte; Harald Schubert; Matthias Schwab
Related Documents :
11373158 - Matrix metalloproteinases (mmp-2 and mmp-9) and tissue inhibitor-2 of matrix metallopro...
20147628 - Chemokine scavenger d6 is expressed by trophoblasts and aids the survival of mouse embr...
1281388 - Multiclefted nuclei. a helpful feature for identification of intermediate trophoblastic...
22309578 - Preconception counseling.
22495578 - Reactivity of blood vessels in response to prostaglandin e(2) in placentas from pregnan...
22475008 - Dynamics of coxiella burnetii antibodies and seroconversion in a dairy cow herd with en...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-18
Journal Detail:
Title:  Stress (Amsterdam, Netherlands)     Volume:  -     ISSN:  1607-8888     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9617529     Medline TA:  Stress     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Neurology, Jena University Hospital , Jena , Germany, 07747.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Isothermal microcalorimetry: a novel method for real-time determination of antifungal susceptibility...
Next Document:  Population transcriptomics of cactus host shifts in Drosophila mojavensis.