Document Detail

Effects of early indomethacin administration on oxygenation and surfactant requirement in low birth weight infants.
MedLine Citation:
PMID:  9078828     Owner:  NLM     Status:  MEDLINE    
A previous study found that early intravenous indomethacin administration prolonged respiratory support in very low birth weight infants. We have, therefore, designed a randomized, double blind controlled study to evaluate the oxygenation, and surfactant requirements in preterm low birth weight infants receiving early indomethacin administration. Premature neonates who received surfactant therapy and on mechanical ventilation were prospectively randomized to receive either placebo or indomethacin (0.2 mg/kg intravenously at 12 postnatal hours and every 24 h for two more doses). Oxygenation was assessed by FiO2 required and arterial/alveolar oxygen (a/A O2) ratio during the first 48 h of life. The doses of surfactant were compared between the two groups. Twenty-seven infants (n = 14 of early indomethacin and n = 13 of placebo group) fulfilled inclusion criteria. At admission to the study, there were no differences in the birth weight, gestational age, sex, Apgar scores, a/A O2 ratio, and FiO2. The control group exhibited a significant improvement in oxygenation (FiO2 requirement and a/A O2 compared with the early indomethacin group at 24 (P = 0.026 and 0.02, respectively) and 48 h of life (P = 0.037 and 0.026, respectively). The requirement of surfactant was significantly larger in the early indomethacin group (P = 0.029). Early indomethacin administration increases oxygen and surfactant requirement.
H Yaseen; K al Umran; H Ali; M Rustum; M Darwich; A al-Faraidy
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of tropical pediatrics     Volume:  43     ISSN:  0142-6338     ISO Abbreviation:  J. Trop. Pediatr.     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-05-12     Completed Date:  1997-05-12     Revised Date:  2006-03-28    
Medline Journal Info:
Nlm Unique ID:  8010948     Medline TA:  J Trop Pediatr     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  42-6     Citation Subset:  IM    
Department of Pediatrics, King Fahd Hospital of the University, Alkhobar, Saudi Arabia.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*
Biological Products*
Double-Blind Method
Ductus Arteriosus, Patent / therapy*
Indomethacin / administration & dosage*
Infant, Low Birth Weight
Infant, Newborn
Infant, Premature
Oxygen / blood
Pulmonary Surfactants / administration & dosage*
Respiration, Artificial
Respiratory Distress Syndrome, Newborn / therapy*
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Biological Products; 0/Pulmonary Surfactants; 108778-82-1/beractant; 53-86-1/Indomethacin; 7782-44-7/Oxygen

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