| Effects of early human recombinant erythropoietin therapy on the transfusion in healthy preterm infants. | |
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MedLine Citation:
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PMID: 19057854 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Early recombinant erythropoietin therapy and iron therapy would decrease the need for red blood cells transfusions and prevents anemia of prematurity. METHODS: Fifty-eight preterm infants in newborn services at Ghaem Medical Center randomly were assigned, among them 18 patients were excluded. A total of 40 preterm infants with gestational age 28-34 weeks, birth weight 1000-1750 g followed the study: 20 infants in treatment group and 20 infants in control group were randomized to treatment (rhu EPO, 500u per kg, per week, 2 times weekly, subcutaneous) and control (no treatment). Therapy was initiated 4 days after birth and continued throughout the 4 weeks. All infants on enteral feeds received supplements: iron 3 mg/kg/d, vitamins and folat. Complete blood cells and reticulocyte counts were measured weekly. Transfusions and phlebotomy data were recorded. Statistical significance was determined by chi-square test, student t test and Mann-Whitney. A P value of < 0.05 was considered statistically significant. RESULTS: The reticulocyte counts were higher in treated infants during the study (p: 0.009). Final hematocrits were higher in treated infants (p: 0.02).The volume of packed red blood cells transfusions mililiter per infant significantly reduced (p: 0.05), the average number of transfusion per infant was also lower for treated infant than control [2 (10 % )vs 8 (40%) respectively]. No adverse effects of EPO or supplemental iron occurred. CONCLUSION: The combination of early rhu EPO and iron as administered in the present study stimulated erythropoiesis and decreased red blood cells transfusion in premature infants who were 1000-1750 g at birth. The enrollments of the larger and healthier preterm infants, who are at lower risk for transfusion, are limitation of the present study. |
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Authors:
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Seyedeh Fatemeh Khatami; Gholamali Mamouri; Mohamad Torkaman |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2008-12-04 |
Journal Detail:
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Title: Indian journal of pediatrics Volume: 75 ISSN: 0973-7693 ISO Abbreviation: Indian J Pediatr Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2009-02-04 Completed Date: 2009-04-20 Revised Date: 2009-07-15 |
Medline Journal Info:
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Nlm Unique ID: 0417442 Medline TA: Indian J Pediatr Country: India |
Other Details:
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Languages: eng Pagination: 1227-30 Citation Subset: IM |
Affiliation:
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Tehran University of Medical Sciences, Tehran, Iran. f_khatami@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anemia, Neonatal
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prevention & control* Erythrocyte Transfusion* Erythropoiesis / drug effects Erythropoietin, Recombinant / therapeutic use* Female Humans Infant, Newborn Infant, Premature* Iron / therapeutic use* Male |
| Chemical | |
Reg. No./Substance:
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0/Erythropoietin, Recombinant; 7439-89-6/Iron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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