Document Detail


Effects of early human recombinant erythropoietin therapy on the transfusion in healthy preterm infants.
MedLine Citation:
PMID:  19057854     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Early recombinant erythropoietin therapy and iron therapy would decrease the need for red blood cells transfusions and prevents anemia of prematurity. METHODS: Fifty-eight preterm infants in newborn services at Ghaem Medical Center randomly were assigned, among them 18 patients were excluded. A total of 40 preterm infants with gestational age 28-34 weeks, birth weight 1000-1750 g followed the study: 20 infants in treatment group and 20 infants in control group were randomized to treatment (rhu EPO, 500u per kg, per week, 2 times weekly, subcutaneous) and control (no treatment). Therapy was initiated 4 days after birth and continued throughout the 4 weeks. All infants on enteral feeds received supplements: iron 3 mg/kg/d, vitamins and folat. Complete blood cells and reticulocyte counts were measured weekly. Transfusions and phlebotomy data were recorded. Statistical significance was determined by chi-square test, student t test and Mann-Whitney. A P value of < 0.05 was considered statistically significant. RESULTS: The reticulocyte counts were higher in treated infants during the study (p: 0.009). Final hematocrits were higher in treated infants (p: 0.02).The volume of packed red blood cells transfusions mililiter per infant significantly reduced (p: 0.05), the average number of transfusion per infant was also lower for treated infant than control [2 (10 % )vs 8 (40%) respectively]. No adverse effects of EPO or supplemental iron occurred. CONCLUSION: The combination of early rhu EPO and iron as administered in the present study stimulated erythropoiesis and decreased red blood cells transfusion in premature infants who were 1000-1750 g at birth. The enrollments of the larger and healthier preterm infants, who are at lower risk for transfusion, are limitation of the present study.
Authors:
Seyedeh Fatemeh Khatami; Gholamali Mamouri; Mohamad Torkaman
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2008-12-04
Journal Detail:
Title:  Indian journal of pediatrics     Volume:  75     ISSN:  0973-7693     ISO Abbreviation:  Indian J Pediatr     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2009-02-04     Completed Date:  2009-04-20     Revised Date:  2009-07-15    
Medline Journal Info:
Nlm Unique ID:  0417442     Medline TA:  Indian J Pediatr     Country:  India    
Other Details:
Languages:  eng     Pagination:  1227-30     Citation Subset:  IM    
Affiliation:
Tehran University of Medical Sciences, Tehran, Iran. f_khatami@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Anemia, Neonatal / prevention & control*
Erythrocyte Transfusion*
Erythropoiesis / drug effects
Erythropoietin, Recombinant / therapeutic use*
Female
Humans
Infant, Newborn
Infant, Premature*
Iron / therapeutic use*
Male
Chemical
Reg. No./Substance:
0/Erythropoietin, Recombinant; 7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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