Document Detail

Effects of early high-dose streptokinase intravenously on left ventricular function in acute myocardial infarction.
MedLine Citation:
PMID:  3307367     Owner:  NLM     Status:  MEDLINE    
One hundred seven patients who recently had acute myocardial infarction were randomly assigned either to standard heparin therapy or to intravenous streptokinase within 5 hours after the onset of symptoms in 7 hospitals without catheterization facilities. In the third week, the patients were referred to a university hospital, where the patency rate of the infarct-related artery was studied by selective coronary arteriography and left ventricular function by radionuclide angiography. Fifty-five patients received heparin and 52 streptokinase within a mean period of 190 minutes after the onset of symptoms. Seven patients in the heparin group and 4 in the streptokinase group died in hospital. The patency rate of the infarct-related artery was identical in both groups (69% in the heparin group vs 68% in the streptokinase group). Left ventricular ejection fraction was not statistically different (0.44 +/- 0.13 in the heparin group vs 0.45 +/- 0.12 in the streptokinase group). Left ventricular ejection fraction was significantly higher in patients with a patent infarct-related artery than in patients with an obstructed infarct-related artery (0.49 +/- 0.12 vs 0.41 +/- 0.15, p less than 0.01). In patients with inferior wall infarction, left ventricular ejection fraction was identical (0.50 +/- 0.10 in the heparin group vs 0.52 +/- 0.09, in the streptokinase group). In patients with anterior wall infarction, left ventricular ejection fraction was significantly higher in the streptokinase group than in heparin group (0.40 +/- 0.10 vs 0.33 +/- 0.09, p less than 0.05). Analysis of regional wall motion revealed that improvement occurred in the lateral wall of the left ventricle.(ABSTRACT TRUNCATED AT 250 WORDS)
J P Bassand; R Faivre; O Becque; C Habert; M Schuffenecker; P Y Petiteau; J C Cardot; J Verdenet; M LaRoze; J P Maurat
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The American journal of cardiology     Volume:  60     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1987 Sep 
Date Detail:
Created Date:  1987-10-19     Completed Date:  1987-10-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  435-9     Citation Subset:  AIM; IM    
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MeSH Terms
Clinical Trials as Topic
Coronary Angiography
Follow-Up Studies
Heart / radionuclide imaging
Heparin / therapeutic use
Infusions, Intravenous
Middle Aged
Myocardial Contraction / drug effects*
Myocardial Infarction / drug therapy*
Random Allocation
Streptokinase / administration & dosage,  therapeutic use*
Stroke Volume
Time Factors
Vascular Patency
Reg. No./Substance:
9005-49-6/Heparin; EC 3.4.-/Streptokinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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