Document Detail

Effects of early experience on responsiveness to ethanol: a preliminary report.
MedLine Citation:
PMID:  3659157     Owner:  NLM     Status:  MEDLINE    
The present study examined the hypothesis that early experiences which alter an organism's response to novel or aversive stimuli and hence its ability to cope with stress might also alter sensitivity to and preference for alcohol. On day 1 of pregnancy, females were assigned to 1 of 5 groups: Handled (H), Nonhandled (NH), Malnourished (MAL), Prenatally stressed (PRE) or Control (CON). Offspring were tested in adulthood to measure their adrenocortical response to stress (ether plus cardiac puncture), adrenocortical response to IP ethanol injection and alcohol preference. Data indicate that early experience did alter responsiveness to stress in adulthood; early handling decreased later stress responsiveness and prenatal stress increased later stress responsiveness. In addition, although early experiences did not alter the corticosterone response to IP ethanol at 60 min post injection, both preweaning handling and perinatal malnutrition reduced alcohol preference in adulthood.
J Weinberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Physiology & behavior     Volume:  40     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1987  
Date Detail:
Created Date:  1987-11-19     Completed Date:  1987-11-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  401-6     Citation Subset:  IM    
Department of Anatomy, University of British Columbia, Vancouver, Canada.
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MeSH Terms
Adrenal Cortex Hormones / blood
Age Factors*
Alcohol Drinking / physiology*
Birth Weight
Stress, Physiological / physiopathology*
Stress, Psychological / physiopathology
Reg. No./Substance:
0/Adrenal Cortex Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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