Document Detail

Effects of early ethanol exposure on dendrite growth of cortical pyramidal neurons: inferences from a computational model.
MedLine Citation:
PMID:  12711375     Owner:  NLM     Status:  MEDLINE    
A computational model has been used to infer rules governing dendritic growth of layer 2/3 associative pyramidal neurons in a rat model of foetal alcohol syndrome. Basal dendrites were studied in adult rats exposed to ethanol during the first postnatal week. Results suggest that ethanol exposure during early postnatal life affects mainly the branching of dendrites rather than their elongation.
Alberto Granato; Jaap Van Pelt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research. Developmental brain research     Volume:  142     ISSN:  0165-3806     ISO Abbreviation:  Brain Res. Dev. Brain Res.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-04-24     Completed Date:  2003-08-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8908639     Medline TA:  Brain Res Dev Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  223-7     Citation Subset:  IM    
Department of Psychology, Catholic University, L.go A. Gemelli 1, 20123, Milan, Italy.
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MeSH Terms
Age Factors
Alcohol-Induced Disorders, Nervous System / pathology,  physiopathology*
Animals, Newborn
Biotin / analogs & derivatives*,  diagnostic use
Cell Differentiation / drug effects*,  physiology
Cell Size / drug effects,  physiology
Cerebral Cortex / drug effects*,  growth & development*,  pathology
Dendrites / drug effects,  pathology
Dextrans / diagnostic use
Disease Models, Animal
Ethanol / adverse effects*
Fetal Alcohol Syndrome / pathology,  physiopathology*
Mental Retardation / chemically induced,  pathology,  physiopathology
Models, Neurological
Pyramidal Cells / drug effects*,  pathology
Rats, Wistar
Reg. No./Substance:
0/biotinylated dextran amine; 58-85-5/Biotin; 64-17-5/Ethanol; 9004-54-0/Dextrans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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