Document Detail

Effects of drugs on the negative (backflow) component of velocity patterns in the dog aorta.
MedLine Citation:
PMID:  1253189     Owner:  NLM     Status:  MEDLINE    
Using an accurately calibrated flowmeter in the descending thoracic aorta of the dog, a study was made of alterations in aortic flow patterns following intravenous and intra-arterial injections of vasoactive drugs. When injected distal to the flowmeter, vasopressors caused marked backflow while vasodilators raised the level of the lowest portion of the pulsatile flow curve. When injected into the brachiocephalic artery, vasopressors prevented the development of a significant negative component whereas vasodilators caused the appearance of backflow, or augmented that which was already present. All acute elevations or decreases in peripheral resistance due to drugs were accompanied by increases in the negative or "backward" phase of flow in diastole. A significant negative flow component was noted only during these acute adjustments. A temporary differential in resistances of the upper and lower portions of the arterial circulation protected cerebral and coronary blood flow during acute haemodynamic adjustments.
P A Kot; J C Rose
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cardiovascular research     Volume:  10     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  1976 Jan 
Date Detail:
Created Date:  1976-06-02     Completed Date:  1976-06-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  119-24     Citation Subset:  IM    
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MeSH Terms
Aorta, Thoracic / drug effects*
Blood Circulation / drug effects
Injections, Intra-Arterial
Injections, Intravenous
Norepinephrine / pharmacology
Phenylephrine / pharmacology
Regional Blood Flow / drug effects
Vascular Resistance / drug effects
Vasoconstrictor Agents / administration & dosage,  pharmacology*
Vasodilator Agents / administration & dosage,  pharmacology*
Reg. No./Substance:
0/Vasoconstrictor Agents; 0/Vasodilator Agents; 51-41-2/Norepinephrine; 59-42-7/Phenylephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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