| Effects of drugs and electrical field stimulation on isolated muscle strips from rabbit pharyngoesophageal segment. | |
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MedLine Citation:
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PMID: 1778096 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Muscle activity of isolated muscle strips from the middle pharyngeal constrictor, the inferior pharyngeal constrictor, the cricopharyngeal muscle, and the cervical esophagus of the rabbit was studied in organ baths in response to drugs and electrical field stimulation. These muscles of the pharyngoesophageal segment seem to lack an autonomic adrenergic and cholinergic innervation, as determined by responses to specific drugs. The nerve-evoked contractile responses of the two lower muscles of the segment were almost completely abolished by the curarelike drug gallamine, suggesting a somatic cholinergic nerve supply. However, in the two upper muscles, the major part of the response was resistant to gallamine, which suggests involvement of non-adrenergic, nonmuscarinic, nonnicotinic receptors in the transmission of nerve impulses in these muscles. These results suggest a differential innervation of the upper and lower pharyngeal muscles. |
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Authors:
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L Malmberg; O Ekberg; J Ekström |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Dysphagia Volume: 6 ISSN: 0179-051X ISO Abbreviation: Dysphagia Publication Date: 1991 |
Date Detail:
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Created Date: 1992-03-09 Completed Date: 1992-03-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8610856 Medline TA: Dysphagia Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 203-8 Citation Subset: D; IM |
Affiliation:
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Department of Physiology, University of Lund, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Deglutition Disorders / physiopathology Electric Stimulation* Esophagus / drug effects*, innervation Female Gallamine Triethiodide / pharmacology Male Muscle Contraction Pharyngeal Muscles / drug effects*, innervation, physiology Rabbits |
| Chemical | |
Reg. No./Substance:
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65-29-2/Gallamine Triethiodide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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