Document Detail

Effects of drugs on the autonomic control of short-term heart rate variability.
MedLine Citation:
PMID:  11485277     Owner:  NLM     Status:  MEDLINE    
The autonomic nervous system links the brain and the heart. Efferent links in the neural control of the heart consist of sympathetic and parasympathetic (vagal) fibers innervating the sinus node. Because sympathetic and vagal firing alter spontaneous sinus node depolarization, cardiac rate and rhythm convey information about autonomic influences on the heart. The easy availability of ECG rendered possible the assessment of sinus rhythm as an index of autonomic outflow. The frequency-domain approach uses non-invasive recordings and appears to provide a quantitative evaluation of the autonomic modulation of cardiovascular function. Spectral profiles resulting from vagal or sympathetic blockades at the cardiac (or vascular) level might be used as references to unravel the mechanism of action of the drug under examination. A more comprehensive assessment will be obtained if spectral analysis is used as a complement to existing techniques applied for describing the neurohumoral status of patients (microneurographic recordings, norepinephrine spillover). This review also reports some pitfalls encountered in variability studies.
J L Elghozi; A Girard; D Laude
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Autonomic neuroscience : basic & clinical     Volume:  90     ISSN:  1566-0702     ISO Abbreviation:  Auton Neurosci     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-08-03     Completed Date:  2001-12-12     Revised Date:  2009-08-12    
Medline Journal Info:
Nlm Unique ID:  100909359     Medline TA:  Auton Neurosci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  116-21     Citation Subset:  IM    
Centre de Pharmacologie Clinique, Hĵpital Necker, Paris, France.
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MeSH Terms
Autonomic Agents / therapeutic use*
Autonomic Nervous System / drug effects,  physiology*
Clinical Trials as Topic
Heart Rate / drug effects,  physiology*
Reg. No./Substance:
0/Autonomic Agents

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