Document Detail

Effects of droperidol dosage on postoperative emetic symptoms following pediatric strabismus surgery.
MedLine Citation:
PMID:  14984857     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVE: To compare the frequency of postoperative emetic symptoms and side effects in pediatric strabismus surgery using four doses of droperidol. DESIGN: Randomized, blinded study. SETTING: University eye institute. PATIENTS: 82 ASA physical status I and II pediatric patients, aged 1 to 16 years, undergoing outpatient strabismus surgery. INTERVENTIONS: Patients were assigned to one of four doses of droperidol (10, 20, 40, or 80 (Groups 1, 2, 3, and 4, respectively). All patients received the same anesthetic management, with droperidol administered intravenously immediately after induction of anesthesia. MEASUREMENTS AND MAIN RESULTS: Postoperatively, patients were evaluated for emetic symptoms (nausea, retching, and/or vomiting) and side effects (postoperative sedation or extrapyramidal symptoms). There was a dose-dependent reduction of emetic symptoms seen with increasing droperidol dose. Predischarge emetic symptoms were 50%, 15%, 15%, and 5% in Groups 1, 2, 3, and 4, respectively (p < 0.009). Peak emetic symptoms were observed after discharge: 75%, 40%, 35%, and 15% in Groups 1, 2, 3, and 4, respectively (p < 0.003). Convalescence times, including awakening, extubation, recovery, and hospitalization, were unaffected by increasing droperidol dose. Sedation was similar in all groups and no patient exhibited any side effects. However, when patients exhibited emetic symptoms, discharge time increased from 207 +/- 57 minutes to 283 +/- 128 minutes (p < 0.001). CONCLUSIONS: Prophylactic administration of droperidol 80 is most effective in reducing postoperative emetic symptoms without increasing time to discharge. In those patients with emetic symptoms who also received prophylactic droperidol, time to discharge was significantly delayed.
Stanley W Stead; Christopher D Beatie; Mary A Keyes; Sherwin J Isenberg
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of clinical anesthesia     Volume:  16     ISSN:  0952-8180     ISO Abbreviation:  J Clin Anesth     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-02-26     Completed Date:  2004-06-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8812166     Medline TA:  J Clin Anesth     Country:  United States    
Other Details:
Languages:  eng     Pagination:  34-9     Citation Subset:  IM    
Department of Anesthesiology, Jules Stein Eye Institute, University of California at Los Angeles, Los Angeles, CA 90095, USA.
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MeSH Terms
Ambulatory Surgical Procedures
Antiemetics / administration & dosage*,  adverse effects
Child, Preschool
Dose-Response Relationship, Drug
Double-Blind Method
Droperidol / administration & dosage*,  adverse effects
Length of Stay
Postoperative Nausea and Vomiting / prevention & control*
Strabismus / surgery*
Reg. No./Substance:
0/Antiemetics; 548-73-2/Droperidol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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