| Effects of dose and formulation of carvacrol and thymol on bacteria and some functional traits of the gut in piglets after weaning. | |
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MedLine Citation:
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PMID: 20481352 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two trials were conducted to study the effects of dose and formulation of carvacrol and thymol on bacterial counts, metabolites and functional traits of the gut in weaned piglets. In the first experiment (Exp. I), 25 piglets (28 d, 6.59 +/- 0.48 kg BW) were allocated to five dietary treatments: a control diet, or the same diet supplemented with either carvacrol or thymol at doses of 500 and 2000 mg kg(-1). In the second experiment (Exp. II), 35 piglets (28 d, 7.99 +/- 0.73 kg BW) were assigned to seven dietary treatments: the same control diet as in Exp. I, or this diet supplemented with thymol in one of three formulations (on celite, on alphacel or microencapsulated) at doses of 500 and 2000 mg kg(-1). At 11/12 days post-weaning piglets were euthanised, and digesta from stomach, proximal and distal small intestine were sampled for bacteriological and biochemical analysis. Small intestinal tissue was sampled for histomorphological determinations. In none of the experiments or sections of the gut was the number of bacteria lowered by the carvacrol or thymol supplementation. In Exp. I, the villus/crypt ratio at the distal small intestine for the experimental diets (1.30-1.32) was higher than for the control diet (1.24) (p < 0.05). Thymol fed animals in Exp. II had a lower number of intra-epithelial lymphocytes at the proximal (p < 0.05) and at the distal (p < 0.1) small intestine as compared to control animals. Mean concentration of the active ingredient in the stomach and proximal small intestine for the 2000 mg kg(-1) carvacrol diet was 521 and 5 mg kg(-1) fresh digesta, respectively, and for the 2000 mg kg(-1) thymol diets it ranged between 475 and 647 and between 13 and 24 mg kg(-1) fresh digesta, respectively. Cumulative absorption in the proximal small intestine was higher than 90% for all treatments and was not affected by formulation type. These data suggest that carvacrol and thymol can improve gut health, but evidence for clear antimicrobial effects towards the major culturable bacteria of the pig foregut is limited. |
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Authors:
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Joris Michiels; Joris Missotten; An Van Hoorick; Anneke Ovyn; Dirk Fremaut; Stefaan De Smet; No?l Dierick |
Publication Detail:
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Type: Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of animal nutrition Volume: 64 ISSN: 1745-039X ISO Abbreviation: Arch Anim Nutr Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-05-20 Completed Date: 2010-06-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101222433 Medline TA: Arch Anim Nutr Country: England |
Other Details:
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Languages: eng Pagination: 136-54 Citation Subset: IM |
Affiliation:
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Faculty of Biosciences and Landscape Architecture, University College Ghent, Ghent, Belgium. joris.michiels@hogent.be |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Bacterial Agents / pharmacology Dose-Response Relationship, Drug Gastrointestinal Tract / drug effects*, microbiology*, physiology Male Monoterpenes / pharmacology* Swine* Thymol / pharmacology* Weaning |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Monoterpenes; 499-75-2/carvacrol; 89-83-8/Thymol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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