Document Detail

Effects of dopexamine on lipid peroxidation during aortic surgery in pigs: comparison with dopamine.
MedLine Citation:
PMID:  16102983     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We investigated the dose-related effect of dopexamine and dopamine on free radical production and lipid peroxidation estimated by MDA measurements in an ischaemia-reperfusion model of supraceliac aortic repair. DESIGN: Prospective, randomized, blinded experimental study. MATERIALS: Twenty-five healthy pigs. METHODS: All experiments were performed under general endotracheal anaesthesia. Supraceliac aortic cross clamping was performed in all pigs. The pigs were randomly assigned into five groups (n=5 in each group) and received a continuous intravenous infusion of normal saline (CTL), dopamine 2 microg kg(-1)min(-1) (dopa 2), dopamine 8 microg kg(-1)min(-1) (dopa 8), dopexamine 2 microg kg(-1)min(-1) (dopex 2), dopexamine 8 microg kg(-1)min(-1) (dopex 8). Cardiac output, mean arterial pressure, arterial blood gas analysis and blood sampling for plasma MDA measurements (to reveal lipid peroxidation) were recorded after induction of anaesthesia (baseline), 60 and 120 min after cross-clamping of aorta (ischaemia phase), and 60 and 120 min after restoration of flow (reperfusion phase). RESULTS: Dopexamine and dopamine at 8 microgkg(-1)min(-1) reduced MDA at 60 and 120 min after reperfusion. CONCLUSION: Dopexamine seems superior to dopamine in reducing oxygen free radicals and subsequent lipid peroxidation during reperfusion after supraceliac aortic cross clamping in pigs.
G Kostopanagiotou; A Pandazi; I Andreadou; A Doufas; I Chondroudaki; T Kotsis; D Rizos; C Costopanagiotou; V Smyrniotis
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2005-08-15
Journal Detail:
Title:  European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery     Volume:  30     ISSN:  1078-5884     ISO Abbreviation:  Eur J Vasc Endovasc Surg     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-11-30     Completed Date:  2006-01-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9512728     Medline TA:  Eur J Vasc Endovasc Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  648-53     Citation Subset:  IM    
2nd Department of Anaesthesiology, School of Medicine, Attikon Hospital, University of Athens, Chaidari, GR-12462 Athens, Greece.
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MeSH Terms
Aortic Aneurysm, Abdominal / blood,  surgery*
Biological Markers / blood
Disease Models, Animal
Dopamine / administration & dosage,  analogs & derivatives*,  therapeutic use
Dopamine Agonists / administration & dosage,  therapeutic use*
Follow-Up Studies
Infusions, Intravenous
Lipid Peroxidation / drug effects*,  physiology
Malondialdehyde / blood
Prospective Studies
Random Allocation
Reperfusion Injury / blood,  etiology,  prevention & control*
Vascular Surgical Procedures / adverse effects*
Reg. No./Substance:
0/Biological Markers; 0/Dopamine Agonists; 542-78-9/Malondialdehyde; 86197-47-9/dopexamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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