| Effects of dopexamine on acute necrotising pancreatitis in rats. | |
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MedLine Citation:
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PMID: 11775728 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To examine the effects of dopexamine on pancreatic tissue oxygen tension (PtO2) and the extent of acinar injury in rats with acute necrotising pancreatitis DESIGN: Laboratory study. SETTING: Medical school, Turkey. ANIMALS: 68 Sprague Dawley rats. MAIN OUTCOME MEASURES: Cardiorespiratory measurements, pancreatic PtO2, effects on activity of serum amylase and concentration trypsinogen activation peptide (TAP). and histological picture. RESULTS: The four study groups (sham + saline, sham + dopexamine, acute pancreatitis and acute pancreatitis + dopexamine) were each divided into two; in 9 rats in each, pancreatic biochemistry was studied, and in the remaining 8 in each group serum biochemistry and histology were studied. The groups were comparable with regard to mean arterial pressure, heart rate, arterial blood gases, packed cell volume, and serum amylase activity. The use of dopexamine increased pancreatic PtO2 in the sham + dopexamine group without the important blood pressure changes. The induction of pancreatitis resulted in a significant reduction in pancreatic PtO2 in the pancreatitis groups. The use of dopexamine did not increase pancreatic PtO2. There were no significant differences in plasma TAP concentration and the extent of acinar cell injury in the animals in the pancreatitis groups. CONCLUSION: Treatment with dopexamine does not improve the pancreatic microcirculation or reduce the extent of acinar cell injury in acute necrotising pancreatitis and is therefore unlikely to be of benefit in patients with pancreatitis. |
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Authors:
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E Alhan; U Küçüktülü; C Erçin; O Deger; R Cicek |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The European journal of surgery = Acta chirurgica Volume: 167 ISSN: 1102-4151 ISO Abbreviation: Eur J Surg Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2002-01-01 Completed Date: 2002-02-28 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9105264 Medline TA: Eur J Surg Country: Norway |
Other Details:
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Languages: eng Pagination: 761-6 Citation Subset: IM |
Affiliation:
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Department of Surgery, Karadeniz Technical University, Kocaeli University, Turkey. alhan@meds.ktu.edu.tr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amylases
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drug effects Animals Blood Gas Analysis Caerulein Disease Models, Animal Dopamine / analogs & derivatives, pharmacology* Hemodynamics / drug effects Male Microcirculation / drug effects, physiology Oxygen Consumption / drug effects Pancreas / blood supply*, drug effects Pancreatitis, Acute Necrotizing / chemically induced, drug therapy* Probability Rats Rats, Sprague-Dawley Reference Values Sensitivity and Specificity Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
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17650-98-5/Caerulein; 86197-47-9/dopexamine; EC 3.2.1.-/Amylases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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