Document Detail

Effects of dopamine and amphetamine on mouse caudate neurons recorded in vitro.
MedLine Citation:
PMID:  3720836     Owner:  NLM     Status:  MEDLINE    
Mouse caudate neurons recorded from brain slices in vitro displayed one of three different types of electrophysiological activity. These were: (a) a regular, pacemaker-like firing pattern; (b) an irregular discharge pattern, and (c) a bursting pattern. Both dopamine and D-amphetamine produced a dose-dependent increase in the activity of the regularly and irregularly firing caudate neurons when placed in the incubation bath, but had no effect on the bursting neurons. These studies demonstrate that the excitatory effect of amphetamine on caudate neurons is due to a direct action on these cells.
M E Trulson; K Arasteh
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  124     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1986 May 
Date Detail:
Created Date:  1986-08-15     Completed Date:  1986-08-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  161-5     Citation Subset:  IM    
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MeSH Terms
Amphetamine / pharmacology*
Caudate Nucleus / drug effects*
Dextroamphetamine / pharmacology
Dopamine / pharmacology*
Neurons / drug effects*
Receptors, Dopamine / drug effects
Reg. No./Substance:
0/Receptors, Dopamine; 300-62-9/Amphetamine; 51-64-9/Dextroamphetamine

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