Document Detail


Effects of dog ownership and genotype on immune development and atopy in infancy.
MedLine Citation:
PMID:  14767447     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Exposure to furred pets might confer protection against the development of allergic sensitization through a mechanism that is incompletely understood. OBJECTIVE: The objective of this study was to determine the effects of pet exposure and genotype on immunologic development and the incidence of atopic markers and diseases in the first year of life. METHODS: Pet exposure in the home was compared with cytokine secretion patterns (mitogen-stimulated mononuclear cells at birth and age 1 year) and indicators of atopy (allergen-specific and total IgE, eosinophilia, food allergy, atopic dermatitis) in 285 infants. Interactions with genotype at the CD14 locus were also evaluated in the data analyses. RESULTS: Exposure to dogs was associated with reduced allergen sensitization (19% vs 33%, P =.020) and atopic dermatitis (30% vs 51%, P <.001). The risk for atopic dermatitis was further influenced by genotype at the CD14 locus (P =.006), even after adjusting for exposure to dogs (P =.003). Furthermore, infants with the genotype -159TT were less likely to develop atopic dermatitis if they were exposed to a dog (5% vs 43%, P =.04). Last, dog exposure was associated with increased IL-10 (117 vs 79 pg/mL, P =.002) and IL-13 (280 vs 226 pg/mL, P =.013) responses at age 1 year. CONCLUSIONS: Having a dog in infancy is associated with higher IL-10 and IL-13 cytokine secretion profiles and reduced allergic sensitization and atopic dermatitis. These findings suggest that postnatal exposure to dogs can influence immune development in a genotype-specific fashion and thereby attenuate the development of atopy in at-risk children.
Authors:
James E Gern; Claudia L Reardon; Sabine Hoffjan; Dan Nicolae; Zhanhai Li; Kathy A Roberg; William A Neaville; Kirstin Carlson-Dakes; Kiva Adler; Rebekah Hamilton; Elizabeth Anderson; Stephanie Gilbertson-White; Christopher Tisler; Douglas Dasilva; Kelly Anklam; Lance D Mikus; Louis A Rosenthal; Carole Ober; Ronald Gangnon; Robert F Lemanske
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  113     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-02-09     Completed Date:  2004-03-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  307-14     Citation Subset:  AIM; IM    
Affiliation:
Department of Pediatrics, University of Wisconsin-Madison, Madison, Wis, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aging / immunology*
Allergens / adverse effects*
Animals
Animals, Domestic*
Antigens, CD14 / genetics*
Cats
Cytokines / biosynthesis*
Dermatitis, Atopic / epidemiology,  etiology
Dogs
Food Hypersensitivity / epidemiology,  etiology
Genotype
Humans
Hypersensitivity, Immediate / epidemiology*,  etiology
Infant
Infant, Newborn
Interleukin-10 / biosynthesis
Interleukin-13 / biosynthesis
Risk Factors
Grant Support
ID/Acronym/Agency:
1R01HL61879-01/HL/NHLBI NIH HHS; 2 M01 RR03186-16/RR/NCRR NIH HHS; P01 HL70831-01/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Allergens; 0/Antigens, CD14; 0/Cytokines; 0/Interleukin-13; 130068-27-8/Interleukin-10

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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