Document Detail

Effects of dobutamine on left ventricular performance in newborns as determined by systolic time intervals.
MedLine Citation:
PMID:  3569349     Owner:  NLM     Status:  MEDLINE    
To evaluate the effects of dobutamine on myocardial function in newborns, left ventricular systolic time intervals (STI) - normalized pre-ejection period (PEPI), normalized left ventricular ejection time (LVETI) and pre-ejection period to left ventricular ejection time ratio (PEP/LVET) - were assessed by echocardiography in 18 newborns treated with dobutamine for clinically diagnosed heart failure. Examinations were performed prior to and 30 min after starting dobutamine infusion (7.5 or 10 micrograms/kg per min). Patients were assigned to two groups according to their PEP/LVET prior to dobutamine administration: group I (n = 9) with pre-treatment PEP/LVET less than or equal to 0.35 and group II (n = 9) with pre-treatment PEP/LVET greater than 0.35. While there was no change of STI in group I, dobutamine infusion resulted in a significant decrease in PEPI (from 102 +/- 4.8 to 87.8 +/- 4.2; mean +/- SEM; P less than 0.01) and of PEP/LVET (from 0.56 +/- 0.05 to 0.45 +/- 0.05; mean +/- SEM; P less than 0.01) and in a significant increase of LVETI (from 237.6 +/- 5.6 to 253.3 +/- 5.2; mean +/- SEM; P less than 0.01) in group II. Heart rate increased significantly in both groups. Left ventricular end-diastolic dimension, also assessed by echocardiography, did not change in the eight studies performed. An increase in mean arterial pressure was found in three out of five newborns of group II and in one out of four patients in group I. It is concluded that dobutamine can improve cardiac performance in newborns with impaired left ventricular function. This effect is probably due to an improvement in myocardial contractility.
H Stopfkuchen; D Schranz; R Huth; B K Jüngst
Related Documents :
9773299 - Dipyridamole stress echocardiography and exercise testing for risk stratification after...
15982489 - Usefulness of strain rate imaging in detecting ischemic myocardium during dobutamine st...
17985199 - Inflammation a possible link between economical stress and coronary heart disease.
8335809 - The dobutamine stress test with thallium-201 single-photon emission computed tomography...
16449519 - Head-to-head comparison of indices of left ventricular contractile reserve assessed by ...
12123319 - Adenosine myocardial perfusion single photon emission computed tomographic stress testi...
20842559 - Treatment of angina and microvascular coronary dysfunction.
22154089 - Effect of hurricane katrina on incidence of acute myocardial infarction in new orleans ...
21173519 - Correlation of left ventricular pressure changes and left atrial function on strain rat...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pediatrics     Volume:  146     ISSN:  0340-6199     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  1987 Mar 
Date Detail:
Created Date:  1987-06-12     Completed Date:  1987-06-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  135-9     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cardiotonic Agents / therapeutic use
Dobutamine / therapeutic use*
Heart Failure / drug therapy*,  physiopathology
Infant, Newborn
Myocardial Contraction / drug effects*
Reg. No./Substance:
0/Cardiotonic Agents; 34368-04-2/Dobutamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Decreased production of specific antibodies to cow's milk proteins in premature infants during the f...
Next Document:  Prolonged indomethacin treatment in preterm infants with symptomatic patent ductus arteriosus: effic...