Document Detail


Effects of dobutamine on coronary circulation and cardiac metabolism of the dog.
MedLine Citation:
PMID:  581958     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Effects of (+/-)-4-[2-(3-p-hydroxyphenyl-1-methyl-amino)ethyl]pyrocatechol (dobutamine) on coronary circulation and cardiac metabolism were investigated using the heart in vivo and the isolated perfused heart of dogs. In the heart in vivo dobutamine 1--30 microgram/kg i.v. and 1--100 microgram i.c. produced dose-dependent increases in coronary perfusion pressure, coronary blood flow, heart rate and left intraventricular pressure. In the perfused heart dobutamine 10 microgram i.c. increased coronary flow, heart rate, cardiac contractility and myocardial oxygen consumption. Delta redox potentials decreased but did not show negative values. Propranolol 0.1 mg/kg i.v. and 0.1 mg i.c. inhibited these effects of dobutamine. Dobutamine shows basically the same actions as isoproterenol, but does not reduce the coronary perfusion pressure by the relatively high dose applied. The results suggest that dobutamine may have a selective adrenergic beta 1 receptor stimulating action on the heart and have a merit in maintaining the coronary perfusion pressure.
Authors:
M Sakanashi; E Tomomatsu; S Takeo; H Araki; K Iwasaki; K Sakamoto; F Takenaka
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Arzneimittel-Forschung     Volume:  28     ISSN:  0004-4172     ISO Abbreviation:  Arzneimittelforschung     Publication Date:  1978  
Date Detail:
Created Date:  1979-06-11     Completed Date:  1979-06-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372660     Medline TA:  Arzneimittelforschung     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  798-801     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Catecholamines / pharmacology*
Coronary Circulation / drug effects*
Dobutamine / pharmacology*
Dogs
Female
Heart Rate / drug effects
Isoproterenol / pharmacology
Male
Myocardial Contraction / drug effects
Myocardium / metabolism*
Oxygen Consumption / drug effects
Chemical
Reg. No./Substance:
0/Catecholamines; 34368-04-2/Dobutamine; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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