| Effects of dipyridamole on collateral flow and regional myocardial function in conscious dogs with newly developed collaterals. | |
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MedLine Citation:
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PMID: 2350328 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Studies were conducted on six conscious dogs instrumented for measurement of subendocardial segment lengths in the area perfused by the left anterior descending coronary artery (LAD) and left circumflex coronary artery (LCCA), LCCA flow, and left ventricular pressure. Externally inflatable occluders were placed around the proximal LAD and LCCA. Collateral channels sufficient for the resting metabolic demands in the occluded LCCA perfusion territory were induced by repeated, brief LCCA occlusions. Dogs were then subjected to two consecutive brief periods of LAD occlusion. Dipyridamole (0.25 mg/kg) was injected intravenously 3 min prior to the second LAD occlusion. The collateral blood flow from the LCCA to the occluded LAD area was measured as the stepwise decrease in LCCA flow upon release of the LAD occlusion. During LAD occlusion after dipyridamole treatment collateral blood flow velocity decreased to 3.8 +/- 1.1 cm/s (+/- standard error) compared with a value of 4.9 +/- 0.9 cm/s measured during LAD occlusion without dipyridamole treatment. Percentage systolic segment shortening in the collateral dependent zone significantly deteriorated from 14.3 +/- 5.2 to 9.7 +/- 5.0% (p less than 0.05). Electrocardiograms taken simultaneously from endocardial ultrasonic transducers in the ischemic segment revealed significant increases in ST-segment level from 4.2 +/- 0.6 to 5.4 +/- 0.6 mV. These findings indicate that dipyridamole adversely affects the extent of myocardial ischemia in the collateral-dependent zone. |
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Authors:
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M Fujita; A Mikuniya; D P McKown; M D McKown; D Franklin |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Basic research in cardiology Volume: 85 ISSN: 0300-8428 ISO Abbreviation: Basic Res. Cardiol. Publication Date: 1990 Mar-Apr |
Date Detail:
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Created Date: 1990-07-12 Completed Date: 1990-07-12 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0360342 Medline TA: Basic Res Cardiol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 142-52 Citation Subset: IM |
Affiliation:
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Dalton Research Center, University of Missouri, Columbia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Cardiac Output / drug effects Collateral Circulation / drug effects* Coronary Circulation / drug effects* Dipyridamole / therapeutic use* Dogs Heart Rate / drug effects Male Myocardial Contraction / drug effects* Regional Blood Flow / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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HL 32800/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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58-32-2/Dipyridamole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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