| Effects of diphenyl diselenide on lipid profile and hepatic oxidative stress parameters in ovariectomized female rats. | |
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MedLine Citation:
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PMID: 21492168 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Objectives Ovarian hormone decline after menopause is linked to many pathophysiological reactions. Female rats submitted to ovariectomy are employed as a model of post-menopausal condition. This study investigated the effects of diphenyl diselenide (PhSe)(2) on body weight gain, intra-abdominal fat deposition, plasma lipid profile and hepatic oxidative stress in ovariectomized rats. Methods Female adult Wistar rats were ovariectomized (OVX rats) or sham-operated and divided into four groups: (i) sham-operated, (ii) (PhSe)(2) , (iii) OVX and (iv) OVX + (PhSe)(2) . (PhSe)(2) (5 mg/kg; 5 ml/kg, p.o.) was administered once a day for 30 days to groups (ii) and (iv). After that, rats were anaesthetized for blood sample gathering and submitted to euthanasia. Key findings (PhSe)(2) (5 mg/kg) was effective in preventing the rise in body weight gain and intra-abdominal fat deposition induced in OVX rats. Although (PhSe)(2) was not effective in avoiding the increase in plasma total cholesterol and non-HDL levels induced in OVX rats, (PhSe)(2) reduced plasma triglycerides and augmented HDL levels in OVX rats. (PhSe)(2) also increased hepatic ascorbic acid levels, reduced glutathione content, glutathione S-transferase activity and restored catalase activity in liver of OVX rats. Conclusions These findings suggest that (PhSe)(2) could be a promising alternative to minimize menopause related symptoms. |
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Authors:
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Juliana Trevisan da Rocha; Simone Pinton; Alexandre Mazzanti; Cinthia Melazzo Mazzanti; Diego Vilibaldo Beckemann; Cristina Wayne Nogueira; Gilson Zeni |
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Publication Detail:
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Type: Journal Article Date: 2011-03-18 |
Journal Detail:
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Title: The Journal of pharmacy and pharmacology Volume: 63 ISSN: 0022-3573 ISO Abbreviation: J. Pharm. Pharmacol. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376363 Medline TA: J Pharm Pharmacol Country: England |
Other Details:
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Languages: eng Pagination: 663-9 Citation Subset: IM |
Copyright Information:
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© 2011 The Authors. JPP © 2011 Royal Pharmaceutical Society. |
Affiliation:
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Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Centro de Ciências Naturais e Exatas Laboratório de Cirurgia Experimental - DCPA, Centro de Ciências Rurais, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil. |
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