Document Detail

Effects of dioxane on RNA synthesis in the rat liver.
MedLine Citation:
PMID:  6173024     Owner:  NLM     Status:  MEDLINE    
The effect of dioxane on transcription was investigated. On intravenous administration of the lower dose (10 mg/rat) both RNA polymerase A and B activities were initially depressed but recovered after 1 h. A secondary effect on RNA polymerase A was observed but the enzyme activity recovered at 24 h when it was about 35% above control values whereas RNA polymerase B activity had achieved control values. With a higher dose (100 mg/rat) the pattern was similar but the suppressive effects were more pronounced - RNA polymerase B activity never attained control values during the times studied whereas there was no increase in RNA polymerase A activity at 24 h.
R N Kurl; L Poellinger; J Lund; J A Gustafsson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of toxicology     Volume:  49     ISSN:  0340-5761     ISO Abbreviation:  Arch. Toxicol.     Publication Date:  1981 Nov 
Date Detail:
Created Date:  1982-03-13     Completed Date:  1982-03-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417615     Medline TA:  Arch Toxicol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  29-33     Citation Subset:  IM    
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MeSH Terms
DNA-Directed RNA Polymerases / antagonists & inhibitors
Dioxanes / pharmacology*
Dioxins / pharmacology*
Liver / drug effects,  metabolism*
RNA / biosynthesis*
Rats, Inbred Strains
Reg. No./Substance:
0/Dioxanes; 0/Dioxins; 123-91-1/1,4-dioxane; 63231-63-0/RNA; EC RNA Polymerases

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