| Effects of dinitrotoluenes on morphological cell transformation and intercellular communication in Syrian hamster embryo cells. | |
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MedLine Citation:
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PMID: 2299690 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of four isomers of dinitrotoluene (DNT) and technical DNT (a mixture of DNT isomers and other compounds, with 2,4-DNT as the major constituent) were studied in two short-term in vitro assays. None of the isomers or technical DNT induced an increase in morphological transformation of Syrian hamster embryo (SHE) cells. Four DNT metabolites (2,4-diaminotoluene, 2-amino-4-nitrotoluene, 2-amino-6-nitrotoluene, and 2,4-dinitobenzoic acid), representing different stages in reduction or oxidation of DNT isomers, were also negative for induction of morphological transformation. The DNT isomers were tested in an intercellular communication assay based on dye transfer. 2,4-DNT, 2,6-DNT, and technical DNT inhibited intercellular communication in the SHE cell line BPNi at toxic concentrations. This may be reminiscent of in vivo data showing promoting activity of these compound. 2,3-DNT and 3,4-DNT did not inhibit communication. |
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Authors:
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I Holen; S O Mikalsen; T Sanner |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of toxicology and environmental health Volume: 29 ISSN: 0098-4108 ISO Abbreviation: J Toxicol Environ Health Publication Date: 1990 |
Date Detail:
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Created Date: 1990-03-01 Completed Date: 1990-03-01 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7513622 Medline TA: J Toxicol Environ Health Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 89-98 Citation Subset: IM |
Affiliation:
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Laboratory for Environmental and Occupational Cancer, Norwegian Radium Hospital, Oslo. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Communication / drug effects Cell Transformation, Neoplastic / chemically induced Cricetinae Dinitrobenzenes / toxicity* Embryo, Mammalian / cytology Isomerism Nitrobenzenes / toxicity* Phenylenediamines / toxicity Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Dinitrobenzenes; 0/Nitrobenzenes; 0/Phenylenediamines; 121-14-2/2,4-dinitrotoluene; 606-20-2/2,6-dinitrotoluene; 610-39-9/3,4-dinitrotoluene; 95-80-7/2,4-diaminotoluene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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