Document Detail

Effects of diltiazem on plasma uric acid level and renal uric acid excretion in rats.
MedLine Citation:
PMID:  2770059     Owner:  NLM     Status:  MEDLINE    
The effects of diltiazem on plasma uric acid level (PUA) and renal uric acid excretion were investigated in oxonate-loaded rats. Diltiazem (0.5 mg/kg, i.v.) decreased PUA without producing uricosuria, and it decreased fractional excretion of uric acid and renal blood flow. The present results suggest that diltiazem produces hypouricemia not accompanied by uricosuria, probably by affecting uric acid metabolism, and it may also cause an alteration in the renal handling of uric acid partly due to changes in renal hemodynamics.
H Sugino; H Shimada
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese journal of pharmacology     Volume:  50     ISSN:  0021-5198     ISO Abbreviation:  Jpn. J. Pharmacol.     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-09-28     Completed Date:  1989-09-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  2983305R     Medline TA:  Jpn J Pharmacol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  239-42     Citation Subset:  IM    
Department of Clinical Pharmacology, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
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MeSH Terms
Blood Pressure / drug effects
Diltiazem / pharmacology*
Glomerular Filtration Rate / drug effects
Rats, Inbred Strains
Renal Circulation / drug effects
Uric Acid / blood,  metabolism*,  urine
Urodynamics / drug effects
Reg. No./Substance:
42399-41-7/Diltiazem; 69-93-2/Uric Acid

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