Document Detail


Effects of diltiazem on the electrophysiological properties of cat ventricular muscle fibers during experimentally induced right ventricular systolic hypertension.
MedLine Citation:
PMID:  6185793     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The electrophysiological effects of diltiazem were studied in right ventricular muscle fibers from normal cats and cats with experimentally induced right ventricular systolic hypertension (RVSH). Two types of action potential (AP) abnormalities were observed in preparations from cats with RVSH: Type I cells, found in most areas of the right ventricular free wall, demonstrated reduced maximum diastolic potential (MDP) (-64.4 mV) and Vmax (89.6 V/s) while Type II cells showed a "slow response" AP configuration (MDP, -48.8 mV; AP amplitude, 48.9 mV; AP duration at 50% repolarization, 47.5 ms; AP duration at 90% repolarization, 90.2 ms; Vmax, 13.1 V/s) and were often monitored near the tricuspid valve. Diltiazem (2.2 X 10(-7) and 2.2 X 10(-6) M) had no effect on MDP of normal, Type I, or Type II cells. Diltiazem at 2.2 X 10(-6) M significantly reduced AP amplitude and Vmax of both Type I and normal cells. In contrast, even at 2.2 X 10(-7) M, diltiazem significantly reduced AP amplitude and Vmax of the Type II cells. Diltiazem, 2.2 X 10(-6) M, would often abolish AP of Type II cells, while Type I cells were more sensitive to tetrodotoxin. AP duration of normal cells was unaffected by diltiazem while that of Type I and II cells was significantly shortened.
Authors:
S S Wong; R J Myerburg; A M Ezrin; M S Gaide; A L Bassett
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  4     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:    1982 Nov-Dec
Date Detail:
Created Date:  1983-03-11     Completed Date:  1983-03-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  986-93     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / drug effects
Animals
Benzazepines / pharmacology*
Blood Pressure / drug effects*
Cats
Diltiazem / pharmacology*
Electrophysiology
Heart / drug effects*,  physiology
Heart Ventricles
Hypertension / drug therapy*
Grant Support
ID/Acronym/Agency:
HL 19044/HL/NHLBI NIH HHS; HL 21735/HL/NHLBI NIH HHS; HL 27680/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Benzazepines; 42399-41-7/Diltiazem

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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