Document Detail

Effects of diltiazem and atenolol on exercise performance in man.
MedLine Citation:
PMID:  2635255     Owner:  NLM     Status:  MEDLINE    
The effects of diltiazem and atenolol on exercise performance were studied in 9 healthy and physically fit volunteers according to a double-blind cross-over design. All subjects performed, with an interval of 1 week, 3 exercise tests on a treadmill with stepwise increase of the workload until exhaustion. Two hours prior to each exercise test they received in a randomised order placebo, diltiazem 120 mg or atenolol 100 mg. Running time and VO2peak were not influenced by diltiazem, while running time was significantly reduced (-10%) after atenolol. The reduction of VO2peak (-9%) after atenolol did not reach statistical significance. Both diltiazem and atenolol significantly decreased heart rate at peak effort but the decrease was much more pronounced after atenolol (-52 b.min-1) than after diltiazem (-6 b.min-1). At submaximal level VO2 was not influenced by diltiazem, but significantly lowered (-6%) after atenolol. Submaximal heart rate was decreased and plasma lactate concentration was increased by both diltiazem and atenolol, but the effect of atenolol was more pronounced. The study shows that maximal work performance of young healthy subjects is not affected by diltiazem 120 mg, in contrast to atenolol 100 mg which decreases maximal work performance in the same subjects.
J Bouckaert; R Lefebvre; J L Pannier
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of sports medicine and physical fitness     Volume:  29     ISSN:  0022-4707     ISO Abbreviation:  J Sports Med Phys Fitness     Publication Date:  1989 Sep 
Date Detail:
Created Date:  1990-06-14     Completed Date:  1990-06-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0376337     Medline TA:  J Sports Med Phys Fitness     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  240-4     Citation Subset:  IM    
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MeSH Terms
Atenolol / pharmacology*
Diltiazem / pharmacology*
Double-Blind Method
Drug Evaluation
Exercise Test / drug effects*
Heart Rate / drug effects
Oxygen Consumption / drug effects
Physical Exertion / drug effects
Physical Fitness
Time Factors
Reg. No./Substance:
29122-68-7/Atenolol; 42399-41-7/Diltiazem

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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